DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP5A and arhgap4a

DIOPT Version :9

Sequence 1:	NP_727007.1	Gene:	RhoGAP5A / 31473	FlyBaseID:	FBgn0029778	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_956738.1	Gene:	arhgap4a / 393416	ZFINID:	ZDB-GENE-040426-1229	Length:	917	Species:	Danio rerio

Alignment Length:	221	Identity:	58/221 - (26%)
Similarity:	95/221 - (42%)	Gaps:	24/221 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   278 VAHSKCSELVPPKCVPDLKRIRGVFGTDLTTMVQLEPHHQIPFVVRRCVEEVEARGMLQEGIYRV 342
            |.|.|.:        |..:..:.:|..||.:.:|.. ...||.||..|:..:...|:..||::||
Zfish   457 VRHKKSN--------PGSQINQKLFNGDLLSYIQAS-GQLIPAVVESCIRFINLNGLHHEGLFRV 512

  Fly   343 SGFADEIEALKLALDR-----EGEKTDMSETAYGNVNVIAGTLKLYLRLLPVPLITFQAYPSFMA 402
            .|....:..||.|.::     ..|:.||..        :||.||||.|.|..||....:|...|.
Zfish   513 PGSQMVVNQLKDAFEKGDDPLTDERCDMDS--------VAGVLKLYFRGLEKPLFPEDSYDQLME 569

  Fly   403 AGRTGKQAEQRQLMAEAVRRLPPAHHSCLQYMLEHLKRVASHYAVNKMNEHNLATVFAPTLIATP 467
            .|:...:.::...:...|...||:....::|:...|..|:.:...|.|..:|||..|.|:|:..|
Zfish   570 CGQIDDETKKVTQLKLIVSSYPPSLIIVMRYLFAFLHHVSQYSDENMMQPYNLAVCFGPSLVRGP 634

  Fly   468 QH--MTNLTEEIFMLSSLITHCKTIF 491
            .:  ...|.....::.|:|...::||
Zfish   635 NNGDAAELQRINALVKSIIIRHESIF 660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP5A	NP_727007.1	SH2_a2chimerin_b2chimerin	75..166	CDD:198215
		C1_1	242..294	CDD:278556	3/15 (20%)
		RhoGAP_chimaerin	302..491	CDD:239837	52/195 (27%)
arhgap4a	NP_956738.1	F-BAR_srGAP	27..252	CDD:153340
		RhoGAP_srGAP	471..655	CDD:239848	52/192 (27%)
		SH3_srGAP4	704..758	CDD:212889
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910