DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP5A and Syde1

DIOPT Version :9

Sequence 1:	NP_727007.1	Gene:	RhoGAP5A / 31473	FlyBaseID:	FBgn0029778	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_001178805.1	Gene:	Syde1 / 362842	RGDID:	1305857	Length:	735	Species:	Rattus norvegicus

Alignment Length:	491	Identity:	116/491 - (23%)
Similarity:	166/491 - (33%)	Gaps:	172/491 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 AGAGNANTGGSGGVGGAPE-PSSPVQKVWKPELYKLQLEAPAPCPLRCQRTLP---LPPAKSTAE 67
            ||...:..||....|.:|| |..|                |:|...|.....|   .|||.
  Rat   219 AGGTRSPRGGYLSDGDSPERPGGP----------------PSPTAFRPYEVGPSARAPPAA---- 263

  Fly    68 AVEANNLAGRLYGSEYHGLMG--------------HLEAEQLLANARDGSYFVRRSP---QSDGY 115
                  |.||| ....:||.|              .|:.:. :|.||.|.  :|..|   :.|..
  Rat   264 ------LWGRL-SLHLYGLGGLRPTPGATPRDLCCLLQVDG-VARARTGP--LRSGPDFLRLDHT 318

  Fly   116 YTLSLRFNKRPKHYKLLYKPGVGHYLRGQDKRFDTVHDMVADGLINFHMQLHASPIIQQINQQTK 180
            :.|.|...:..:...|.:.|||..            |...|.|.:       ..|.|      .:
  Rat   319 FHLELEAARLLRALVLAWDPGVRR------------HRPCAQGTV-------LLPTI------FR 358

  Fly   181 NCYQQSPYMTLNGRKLRALSNELGKAAAKESKESPAEEKEQKQEEPPPPAVDPMPLVYEKPHHFK 245
            .|..|...:.|..:.|.     ..|....|.:|:||             .|:|.
  Rat   359 GCQAQQLAVRLEPQGLL-----YAKLTLSEQQEAPA-------------TVEPR----------- 394

  Fly   246 VHTFKGLNWCEFCANFLWGFTAQGVKCEACGFVAHSKCSELVPPKCVPDLKRIRGVFGTDLTTMV 310
                                                                   |||..|..:|
  Rat   395 -------------------------------------------------------VFGLPLQLLV 404

  Fly   311 QLEPH-HQIPFVVRRCVEEVEARGMLQEGIYRVSGFADEIEALKLALDREGEKTDMSETAYGNVN 374
            :.|.. .|:|.::|:||.::|.||:...|:||:.|.|...:.|:.|.:::.....:||..|.::|
  Rat   405 EREQSPGQVPLIIRKCVGQIECRGLRVVGLYRLCGSAAVKKELRDAFEQDSAAVCLSEDVYPDIN 469

  Fly   375 VIAGTLKLYLRLLPVPLIT---FQAYPSFMAAGRTGKQAEQRQLMAEAVRR----LPPAHHSCLQ 432
            ||.|.||.|||.||.||||   :|.....||.|...:.:    |..|..|.    ||....:.|.
  Rat   470 VITGILKDYLRELPTPLITQPLYQVVLEAMAQGHPSRAS----LGPEGTRGLLSCLPDVERATLT 530

  Fly   433 YMLEHLKRVASHYAVNKMNEHNLATVFAPTLIATPQ 468
            .:|:||:.|:|.:..|:|...|||..|.|.|:...|
  Rat   531 LLLDHLRLVSSFHTHNRMTPQNLAVCFGPVLLPARQ 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP5A	NP_727007.1	SH2_a2chimerin_b2chimerin	75..166	CDD:198215	23/107 (21%)
		C1_1	242..294	CDD:278556	0/51 (0%)
		RhoGAP_chimaerin	302..491	CDD:239837	62/175 (35%)
Syde1	NP_001178805.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..253		12/49 (24%)
		PHA03247	<48..263	CDD:223021	15/59 (25%)
		RhoGAP	396..601	CDD:413382	62/175 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	601..655
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	669..706
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1300981at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010