DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP5A and Arhgap32

DIOPT Version :9

Sequence 1:	NP_727007.1	Gene:	RhoGAP5A / 31473	FlyBaseID:	FBgn0029778	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	XP_006510505.1	Gene:	Arhgap32 / 330914	MGIID:	2450166	Length:	2103	Species:	Mus musculus

Alignment Length:	405	Identity:	99/405 - (24%)
Similarity:	167/405 - (41%)	Gaps:	75/405 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 SYFVRRSPQSDGYYTLSLRFNKRPKHYKL-LYKPGVGHYLRGQDKRFDTVHDMVADGLINFHMQL 166
            |:.|:||.:.         |....||..| :|           |:||..:.::....:      |
Mouse   180 SWIVKRSYED---------FRVLDKHLHLCIY-----------DRRFSQLTELPRSDV------L 218

  Fly   167 HASP--IIQQINQQTK----------NCYQQSPYMTLNGRKLRALSNE--------LGKA----- 206
            ..||  :.|.:.....          ||.....:|.::.:....|.:|        :|.|
Mouse   219 KDSPESVTQMLTAYLSRLSTIAGNKINCGPALTWMEIDNKGNHLLVHEESSINTPAVGAAHVIKR 283

  Fly   207 -AAKESKESPAEEKEQKQEEPPPPAVDPMPLVYEKPHHFKVHTFKGLNWCEFCANFLWGFTAQGV 270
             .|:...|...|..:.......||.|  :...:...|.|:|..|.|     .|...:.....|.|
Mouse   284 YTARAPDELTLEVGDIVSVIDMPPKV--LSTWWRGKHGFQVGLFPG-----HCVELINQKVPQSV 341

  Fly   271 KCEACGFVA--HSKCSELVPP--KCVPDLKRI--RG-----VFGTDLTTMVQLEPHHQIPFVVRR 324
            .......|:  |.|....:..  |..|..:::  ||     |||.||...: |....::|.|::.
Mouse   342 TNSVPKPVSKKHGKLITFLRTFMKSRPTKQKLKQRGILKERVFGCDLGEHL-LNSGFEVPQVLQS 405

  Fly   325 CVEEVEARGMLQEGIYRVSGFADEIEALKLALDREGEKTDMSETAY-GNVNVIAGTLKLYLRLLP 388
            |...:|..|:: :||||:||.|..|:.|:...|.| ...|:::..| .:::.:....|||.|.||
Mouse   406 CTAFIERYGIV-DGIYRLSGVASNIQRLRHEFDSE-HVPDLTKEPYVQDIHSVGSLCKLYFRELP 468

  Fly   389 VPLITFQAYPSFMAAGRTGKQAEQRQLMAEAVRRLPPAHHSCLQYMLEHLKRVASHYAVNKMNEH 453
            .||:|:|.|..|..|.......|:...:.:.:::|||.|:..|::::.||..:|.:.::..|:..
Mouse   469 NPLLTYQLYEKFSDAVSAATDEERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAK 533

  Fly   454 NLATVFAPTLIATPQ 468
            |||.|:||.|:.:.|
Mouse   534 NLAIVWAPNLLRSKQ 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP5A	NP_727007.1	SH2_a2chimerin_b2chimerin	75..166	CDD:198215	12/63 (19%)
		C1_1	242..294	CDD:278556	12/55 (22%)
		RhoGAP_chimaerin	302..491	CDD:239837	54/168 (32%)
Arhgap32	XP_006510505.1	PX_RICS	141..255	CDD:132831	19/100 (19%)
		SH3_ARHGAP32_33	277..330	CDD:212769	12/59 (20%)
		RhoGAP_CdGAP	382..576	CDD:239849	55/170 (32%)
		PHA03247	<1251..1633	CDD:223021
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1300981at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920