Protein Alignment RhoGAP5A and RhoGAP19D

DIOPT Version :10

• Sequence 1: NP_727007.1
• Gene: RhoGAP5A / 31473
• FlyBaseID: FBgn0029778
• Length: 494
• Species: Drosophila melanogaster
• Sequence 2: NP_001285496.1
• Gene: RhoGAP19D / 33048
• FlyBaseID: FBgn0031118
• Length: 2206
• Species: Drosophila melanogaster
• Alignment Length: 649
• Identity: 137/649 - (21%)
• Similarity: 210/649 - (32%)
• Gaps: 238/649 - (36%)

  Fly     4 NTEAGAGN--ANTGGSGGVGGAPEPSSPVQKVWKPELYKLQLEAPAPCPLRCQRTLPLPPA---- 62
            |.||.||.  |.||.||....:...|:|     .|........||||.||..  ::|:|.|
  Fly   793 NAEAAAGGDAAATGASGPASASAASSAP-----GPTPSSAPAPAPAPAPLPI--SIPIPVAAVVE 850

  Fly    63 -KSTAEAVEANN------LAGRLYGSEYHGLMGHLEAEQLLANARDGSYFVRRSPQS-------- 112
             :.|...||.:.      :.|...|.|:      :|....|.:.|..::..||:..|
  Fly   851 PQKTKSLVEEHPDPTYDVIGGTGGGHEF------IETPNGLEDVRLSAHGSRRASMSSDMRSSIH 909

  Fly   113 -----DGYYT----------LSLRFN----KRPKHY------KLLYKPGVGHYLRGQDKRFDTVH 152
                 :|.|.          :.::.:    ||...|      ||..|..:.....|:..:.:  |
  Fly   910 IDAELNGKYVPNELEAFETEIEIKSSCINGKRMSEYRSWRQVKLEIKGDLLRIYSGRHAKSE--H 972

  Fly   153 DMVADGLINF--------------HMQLHASPIIQQINQQTKNCYQQSPYMTLNGRKLRALSNEL 203
            :::...:.||              .||...||                     :|..|.:|.|||
  Fly   973 NVIELDIRNFKFFDESMDKKKYLIRMQSKPSP---------------------SGAHLASLGNEL 1016

  Fly   204 -------------GKAAAKESKESPA--------------------------------------- 216
                         |.::|.|...:.|
  Fly  1017 NLDEGHDKLLTSSGSSSANEPAANAASALTASTSSSTCSSGPYTEILFKTKSSNEMKRLFGLLQW 1081

  Fly   217 ---------EEKEQKQEEPPP-----------------PAVDPMPLVYEK--------PHHFKV- 246
                     |.:.|.::...|                 .|.|..||....        .||...
  Fly  1082 KDSLNYDDNEHQPQGKQLAEPQKTVASASYLDDVQGGASAADSSPLSSHSGGIADASGSHHVSAL 1146

  Fly   247 -------------------------HTF---------KGLNWCEFCANFLWGFTAQGVKCEACGF 277
                                     |..         |..||.:..  |..|.:..|      |.
  Fly  1147 PAAAAIVAATSDSISPVMKARKSSSHKHIPDKDLGSPKSKNWKDLL--FRRGGSGSG------GV 1203

  Fly   278 VAHSKCSELVPPKCVPDLKRIRGVFGTDLTTMVQLEPHHQIPFVVRRCVEEVEARGMLQEGIYRV 342
            ..|...|   |..|.  .|:| |..|..|.:....:.:..:|.:|..|...||.:|:...||||:
  Fly  1204 SHHDLAS---PSACA--AKQI-GSIGVPLRSCPMSKVNAYVPHLVEVCTNIVETKGLGVVGIYRI 1262

  Fly   343 SG---FADEIEALKLALDREGEKTDMSETAYGNVNVIAGTLKLYLRLLPVPLITFQAYPSFMAAG 404
            .|   ...|:..|....|.:.|.. .|:..:.:|||::..|||::|.||..|:....|.:|:.|.
  Fly  1263 PGNKAAISELSELVNTKDFQFESC-ASDDRWEDVNVVSSLLKLFIRSLPDALMPASYYINFIEAD 1326

  Fly   405 RT-GKQAEQRQLMAEAVRRLPPAHHSCLQYMLEHLKRVASHYAVNKMNEHNLATVFAPTLIATP 467
            :. |  .|:..|:.|.|..||...:..:::::.||.||:.:..||:|...|||.:|.|::|.||
  Fly  1327 KKFG--LERIVLLREIVESLPRHPYETMKHLIRHLCRVSGNCDVNRMEPKNLAIIFGPSIIRTP 1388

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP5A	NP_727007.1	SH2_a2chimerin_b2chimerin	75..166	CDD:198215	22/137 (16%)
		C1_CHN	241..293	CDD:410356	14/86 (16%)
		RhoGAP_chimaerin	302..491	CDD:239837	53/170 (31%)
RhoGAP19D	NP_001285496.1	PDZ_canonical	52..204	CDD:483948
		RhoGAP_ARHGAP21	1221..1417	CDD:239860	53/171 (31%)