DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP5A and Arhgap32

DIOPT Version :9

Sequence 1:	NP_727007.1	Gene:	RhoGAP5A / 31473	FlyBaseID:	FBgn0029778	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	XP_017451485.1	Gene:	Arhgap32 / 315530	RGDID:	1305267	Length:	2100	Species:	Rattus norvegicus

Alignment Length:	407	Identity:	99/407 - (24%)
Similarity:	167/407 - (41%)	Gaps:	79/407 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 SYFVRRSPQSDGYYTLSLRFNKRPKHYKL-LYKPGVGHYLRGQDKRFDTVHDMVADGLINFHMQL 166
            |:.|:||.:.         |....||..| :|           |:||..:.::....:      |
  Rat   180 SWIVKRSYED---------FRVLDKHLHLCIY-----------DRRFSQLSELPRSDI------L 218

  Fly   167 HASPIIQQINQQTK--------------NCYQQSPYMTLNGRKLRALSNE--------LGKA--- 206
            ..||  :.:.|...              ||.....:|.::.:....|.:|        :|.|
  Rat   219 KDSP--ESVTQMLAAYLSRLSTIAGNKINCGPALTWMEIDNKGNHLLVHEESSINTPAVGAAHVI 281

  Fly   207 ---AAKESKESPAEEKEQKQEEPPPPAVDPMPLVYEKPHHFKVHTFKGLNWCEFCANFLWGFTAQ 268
               .|:...|...|..:.......||.|  :...:...|.|:|..|.|     .|...:.....|
  Rat   282 KRYTARAPDELTLEVGDIVSVIDMPPKV--LSTWWRGKHGFQVGLFPG-----HCVELINQKVPQ 339

  Fly   269 GVKCEACGFVA--HSKCSELVPP--KCVPDLKRI--RG-----VFGTDLTTMVQLEPHHQIPFVV 322
            .|.......|:  |.|....:..  |..|..:::  ||     |||.||...: |....::|.|:
  Rat   340 SVTNSVPKPVSKKHGKLITFLRTFMKSRPTKQKLKQRGILKERVFGCDLGEHL-LNSGFEVPQVL 403

  Fly   323 RRCVEEVEARGMLQEGIYRVSGFADEIEALKLALDREGEKTDMSETAY-GNVNVIAGTLKLYLRL 386
            :.|...:|..|:: :||||:||.|..|:.|:...|.| ...|:::..| .:::.:....|||.|.
  Rat   404 QSCTAFIERYGIV-DGIYRLSGVASNIQRLRHEFDSE-HVPDLTKEPYVQDIHSVGSLCKLYFRE 466

  Fly   387 LPVPLITFQAYPSFMAAGRTGKQAEQRQLMAEAVRRLPPAHHSCLQYMLEHLKRVASHYAVNKMN 451
            ||.||:|:|.|..|..|.......|:...:.:.:::|||.|:..|::::.||..:|.:.::..|:
  Rat   467 LPNPLLTYQLYEKFSDAVSAATDEERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMH 531

  Fly   452 EHNLATVFAPTLIATPQ 468
            ..|||.|:||.|:.:.|
  Rat   532 AKNLAIVWAPNLLRSKQ 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP5A	NP_727007.1	SH2_a2chimerin_b2chimerin	75..166	CDD:198215	12/63 (19%)
		C1_1	242..294	CDD:278556	12/55 (22%)
		RhoGAP_chimaerin	302..491	CDD:239837	54/168 (32%)
Arhgap32	XP_017451485.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1300981at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920