DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP5A and Arhgap45

DIOPT Version :9

Sequence 1:	NP_727007.1	Gene:	RhoGAP5A / 31473	FlyBaseID:	FBgn0029778	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	XP_038934906.1	Gene:	Arhgap45 / 314618	RGDID:	1308662	Length:	1127	Species:	Rattus norvegicus

Alignment Length:	506	Identity:	122/506 - (24%)
Similarity:	190/506 - (37%)	Gaps:	171/506 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 VRRSPQSDGYYTLSLRFNKRPKHYKLLYKPGVGHYLRGQDKRFDTVHDMVADGLINFHM------ 164
            :|:|.|:....|:|        :|:|:                   |...|...:||.|
  Rat   505 IRQSDQTIKSATIS--------YYQLM-------------------HMQTAPLPVNFQMLCESSK 542

  Fly   165 -----QLHASPIIQ-QINQQTKNCYQQSPYMTLNG----RKLRALSNELGKAAAKESKESPAEE- 218
                 |.:||.:.| |..::....|...||::.|.    .:.|..|...|.|:..|:..||.||
  Rat   543 LYDPGQQYASHVRQLQRGEEPDVRYDFEPYVSTNAWSPIMRTRKGSFNPGDASGPEAAGSPPEEG 607

  Fly   219 --------KEQK-------------------------------------------------QE-- 224
                    |:.:                                                 ||
  Rat   608 GTSEGAPNKDHRGGRGHQVHKSWPISISDTEVSLDVSSGDLKKFDRTSSSGTMSSNEELVDQEAG 672

  Fly   225 --------------EPPPPAVDPM-PLVYEKPHHF------KVHTFKGLNW---CEFCANFLWGF 265
                          :|..|...|. |.     .|.      :.|..:.|..   |..|.::::
  Rat   673 LVASAFDSADLNGMDPELPVAMPSGPF-----RHVGLSKAARTHRLRKLRTPAKCRECNSYVY-- 730

  Fly   266 TAQGVKCEACGFVAHSKCSELVPPKCVPDLKRIRG---VFGTDLTTMVQLEPHHQIPFVVRRCVE 327
             .||.:||.|....|.||.|.:..:|  ..|:::|   :||.|.:......| ..:||::::||.
  Rat   731 -FQGAECEECCLACHKKCLETLAIQC--GHKKLQGRLQLFGQDFSQAAHSTP-DGVPFIIKKCVC 791

  Fly   328 EVEARGMLQEGIYRVSGFADEIEALKLALDREGEKTDMSETAYGNVNVIAGTLKLYLRLLPVPLI 392
            |:|.|.:..:|||||:|....:|.|..|.:...|..::|:   .:.:.|:..||||||.||.|||
  Rat   792 EIERRALHTKGIYRVNGVKTRVEKLCQAFENGKELVELSQ---ASPHDISNVLKLYLRQLPEPLI 853

  Fly   393 TFQAYPSFM--------------AAGR---TGKQAEQRQL-----MAEAVRRLPPAHHSCLQYML 435
            :|:.|...:              ||.|   .|.::|...|     :.|.:|.||..:.:.|.|:|
  Rat   854 SFRFYHELVGLAKDSLKAEAEAKAASRGRQDGSESEAATLAMVGRLRELMRDLPAENRATLLYLL 918

  Fly   436 EHLKRVASHYAVNKMNEHNLATVFAPTLIATPQHMTNLTEEIFMLSSLITH 486
            .||:|:......|||...||..||.|||: .|:.    |:....||||:.:
  Rat   919 RHLRRIVEMEQDNKMTPGNLGIVFGPTLL-RPRP----TDATVSLSSLVDY 964

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP5A	NP_727007.1	SH2_a2chimerin_b2chimerin	75..166	CDD:198215	12/70 (17%)
		C1_1	242..294	CDD:278556	15/60 (25%)
		RhoGAP_chimaerin	302..491	CDD:239837	68/207 (33%)
Arhgap45	XP_038934906.1	BAR	289..540	CDD:416402	12/61 (20%)
		C1_GMIP-like	709..759	CDD:410366	14/54 (26%)
		RhoGAP	767..977	CDD:413382	68/207 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1453
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1300981at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820