DRSC/TRiP Functional Genomics Resources

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Protein Alignment RhoGAP5A and Arhgap29

DIOPT Version :9

Sequence 1:NP_727007.1 Gene:RhoGAP5A / 31473 FlyBaseID:FBgn0029778 Length:494 Species:Drosophila melanogaster
Sequence 2:XP_006233301.1 Gene:Arhgap29 / 310833 RGDID:1306185 Length:1271 Species:Rattus norvegicus


Alignment Length:488 Identity:130/488 - (26%)
Similarity:200/488 - (40%) Gaps:97/488 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    62 AKSTAEAVEANNLAGRLY--GSEYHGLMGHLEAEQLLANARDGSY--FVRRSPQSDGYYTL-SLR 121
            |.|.|.::::...:.:||  |.||...:....:.:|.... ||:.  .:..|||:.||... ||.
  Rat   440 AASLANSLQSLCDSAKLYDPGQEYSEFVKATSSSELEEKV-DGNVNKQIASSPQTSGYEPADSLE 503

  Fly   122 FNKRPKHYKLLYKPGVGHYLRGQDKRFDTVHDMVADGLI---NFHMQLHASPIIQQINQQTKNCY 183
            ...|        .|...|.|  ::.|.....||.....|   .|.|                  :
  Rat   504 DVAR--------LPDSCHKL--EEDRCSNSADMTGPSFIRSWKFGM------------------F 540

  Fly   184 QQSPYMTLNGRKLRALSNEL-------GKAAAKESKESPAEEKEQKQEEPPPPA-VDPMPL-VYE 239
            ..|. .|....:.|:|.:|.       .|.....|..:.:...:..:.|||.|: ..|..| .::
  Rat   541 SDSE-STGGSSESRSLDSESISPGDFHRKLPRTPSSGTMSSADDLDEREPPSPSEAGPNSLGTFK 604

  Fly   240 KPHHFK---VHTFKGL---NWCEFCANFLWGFTAQGVKCEACGFVAHSKCSELVPPKCVPDLKRI 298
            |....|   .|.|:.|   ..|..|...:   ...||:||.|..|.|.||.|.:...|  ..:::
  Rat   605 KTLMSKAALTHKFRKLRSPTKCRDCEGIV---MFPGVECEECLLVCHRKCLENLVIVC--GHQKL 664

  Fly   299 RG---VFGTDLTTMVQLEPHHQIPFVVRRCVEEVEARGMLQEGIYRVSGFADEIEALKLALDREG 360
            :|   :||.:...:.:.|| ..||||::.|..|:|:|.:..:|||||.|...:.|.|..||:...
  Rat   665 QGKMHIFGAEFIQVAKKEP-DGIPFVLKICASEIESRALCLQGIYRVCGNKIKTEKLCQALENGM 728

  Fly   361 EKTDMSETAYGNVNVIAGTLKLYLRLLPVPLITFQAYPSFMAAGRTGKQAEQRQ----------- 414
            ...|:||.:..:   |...||||||.||.|.|.|:.|..|:...:..:...:.|           
  Rat   729 HLVDISEFSSHD---ICDVLKLYLRQLPEPFILFRLYKEFIDLAKEIQHVNEEQEAKKDSPEDKK 790

  Fly   415 -------------LMAEAVRRLPPAHHSCLQYMLEHLKRVASHYAVNKMNEHNLATVFAPTLI-- 464
                         ...:.:|:||.::.:.|.|::.|||||..|...||||..||..:|.||||  
  Rat   791 HPHVSIEINRILLRSKDLLRQLPASNFNSLHYLIVHLKRVVDHAEENKMNSKNLGVIFGPTLIRP 855

  Fly   465 ---ATPQHMTNLTE---EIFMLSSLITHCKTIF 491
               ..|..:::|.|   :..::..|||:.:.||
  Rat   856 RPTTAPVTISSLAEYSSQARVVEFLITYAQKIF 888

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGAP5ANP_727007.1 SH2_a2chimerin_b2chimerin 75..166 CDD:198215 25/98 (26%)
C1_1 242..294 CDD:278556 17/57 (30%)
RhoGAP_chimaerin 302..491 CDD:239837 68/220 (31%)
Arhgap29XP_006233301.1 BAR 220..436 CDD:416402
C1_GMIP-like 613..663 CDD:410366 16/54 (30%)
RhoGAP 671..883 CDD:413382 67/215 (31%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1453
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1300981at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.820

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