DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP5A and Arhgap12

DIOPT Version :9

Sequence 1:	NP_727007.1	Gene:	RhoGAP5A / 31473	FlyBaseID:	FBgn0029778	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_001100827.2	Gene:	Arhgap12 / 307016	RGDID:	1310017	Length:	838	Species:	Rattus norvegicus

Alignment Length:	334	Identity:	86/334 - (25%)
Similarity:	156/334 - (46%)	Gaps:	56/334 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   171 IIQQINQQTKNCYQQSPYMTLNGRKLRALSNELGKAAAKESKESPAEEKEQKQEEPPPPAVDPMP 235
            :||..|....|.:.:....|:|.:..     |..:||.:|:.:||..||:.|::
  Rat   546 LIQSDNDAVINDWFKVLSSTINNQVA-----EADEAAEEEAPDSPGVEKQDKEK----------- 594

  Fly   236 LVYEKPHHFKVHTFKGLNWCEFCANFLWGFTAQGVKCEACGFVAHSKCSELVPPKCVPDLKRIR- 299
               ::....|:.:.||        :.:.....:..|.....|:...           |.|:.:|
  Rat   595 ---DQKELKKLRSMKG--------SSMDSSEQKKTKKNLKKFLTRR-----------PTLQAVRE 637

  Fly   300 ------GVFGTDLTTMVQLEPHHQIPFVVRRCVEEVEARGMLQEGIYRVSGFADEIEALKLALDR 358
                  .|||::|..:.|.| :..:|..|:.|:|.||..|:..:|||||||....|:.|:.|::.
  Rat   638 KGYIKDQVFGSNLANLCQRE-NGTVPKFVKLCIEHVEEHGLDVDGIYRVSGNLAVIQKLRFAVNH 701

  Fly   359 EGEKTDMSETAYGNVNVIAGTLKLYLRLLPVPLITFQAYPSFMAAGRTGKQAEQRQLMA--EAVR 421
            : ||.|::::.:.:::||.|.||::.|.||.||.||..:..|:.|   .||..::::.|  :.:|
  Rat   702 D-EKLDLNDSKWEDIHVITGALKMFFRELPEPLFTFNHFNDFVNA---IKQEPRQRVTAVKDLIR 762

  Fly   422 RLPPAHHSCLQYMLEHLKRVASHYAVNKMNEHNLATVFAPTLIATPQHMTNLTEEIF----MLSS 482
            :||..:...:|.:..|||||..:...|:|...::|.||.|||:...:...|:.....    ::..
  Rat   763 QLPKPNQDTMQILFRHLKRVIENGEKNRMTYQSIAIVFGPTLLKPERETGNIAVHTVYQNQIVEL 827

  Fly   483 LITHCKTIF 491
            ::....|:|
  Rat   828 ILLELSTVF 836

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP5A	NP_727007.1	SH2_a2chimerin_b2chimerin	75..166	CDD:198215
		C1_1	242..294	CDD:278556	5/51 (10%)
		RhoGAP_chimaerin	302..491	CDD:239837	61/194 (31%)
Arhgap12	NP_001100827.2	SH3_ARHGAP12	13..72	CDD:213003
		SH3-WW_linker	69..264	CDD:406914
		WW	266..296	CDD:238122
		PH_ARHGAP9-like	457..568	CDD:270053	5/21 (24%)
		RhoGAP_ARHGAP27_15_12_9	646..831	CDD:239868	60/189 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1300981at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920