Protein Alignment RhoGAP5A and Arhgap22

DIOPT Version :10

• Sequence 1: NP_727007.1
• Gene: RhoGAP5A / 31473
• FlyBaseID: FBgn0029778
• Length: 494
• Species: Drosophila melanogaster
• Sequence 2: XP_038950392.1
• Gene: Arhgap22 / 306279
• RGDID: 1307237
• Length: 722
• Species: Rattus norvegicus
• Alignment Length: 258
• Identity: 81/258 - (31%)
• Similarity: 123/258 - (47%)
• Gaps: 42/258 - (16%)

  Fly   253 NWCEFCANFLWGFTAQGVKCEACGFVAHSKCSELVPPKCVPDLKRIRGVFGTDLTTMVQLEPHHQ 317
            :|.:.....:|.....|.          |:.|...|   |..|.  .|:||..|...|    ||:
  Rat   141 DWVQAIRRVIWAPLGGGT----------SRSSHAHP---VEPLS--TGIFGQRLEDTV----HHE 186

  Fly   318 -------IPFVVRRCVEEVEARGMLQEGIYRVSGFADEIEALKLALDREGEKTDMSETAYGNVNV 375
                   .|.:|.:||:.:..||:.:||::|:.|.|:.:..|:.:.|. |||.....|.  :|:.
  Rat   187 RKFGPRLAPLLVEQCVDFIRERGLSEEGLFRMPGQANLVRDLQDSFDC-GEKPLFDSTT--DVHT 248

  Fly   376 IAGTLKLYLRLLPVPLITFQAYPSFMAAGR--TGKQAEQRQLMAEAVRRLPPAHHSCLQYMLEHL 438
            :|..||||||.||.|:|.|..|..|::..:  |..:.|....:|:.|..||.|:::.|:|:...|
  Rat   249 VASLLKLYLRELPEPVIPFARYEDFLSCAQLLTKDEGEGTVELAKQVSNLPQANYNLLRYICRFL 313

  Fly   439 KRVASHYAVNKMNEHNLATVFAPTLIATPQHMTNLTEEIFMLSSLITHCKTI--------FAT 493
            ..|.:|..||||:..||||||.|.:: .||....:|  |...:||:.|..|:        |||
  Rat   314 DEVQAHSDVNKMSVQNLATVFGPNIL-RPQVEDPVT--IMEGTSLVQHLMTVLIRKHGQLFAT 373

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP5A	NP_727007.1	SH2_a2chimerin_b2chimerin	75..166	CDD:198215
		C1_CHN	241..293	CDD:410356	6/39 (15%)
		RhoGAP_chimaerin	302..491	CDD:239837	69/205 (34%)
Arhgap22	XP_038950392.1	PH-like	42..157	CDD:473070	2/15 (13%)
		RhoGAP_ARHGAP22_24_25	173..371	CDD:239855	70/207 (34%)
		DUF4670	<388..>703	CDD:464815
		SMC_prok_B	<614..>704	CDD:274008