Protein Alignment RhoGAP5A and ABR

DIOPT Version :9

• Sequence 1: NP_727007.1
• Gene: RhoGAP5A / 31473
• FlyBaseID: FBgn0029778
• Length: 494
• Species: Drosophila melanogaster
• Sequence 2: XP_016880028.1
• Gene: ABR / 29
• HGNCID: 81
• Length: 1137
• Species: Homo sapiens
• Alignment Length: 509
• Identity: 131/509 - (25%)
• Similarity: 199/509 - (39%)
• Gaps: 143/509 - (28%)

  Fly    34 WKPELYKLQ---LEAPAPCPLRCQ---------RTLPLPPAKSTAEAVEANNLAGRLYGSEYHGL 86
            |:..:.|||   |:|.....:..|         ||:...|..|..:..|:..|.|.|: ...|..
Human   709 WREAIQKLQKKDLQAFVLSSVELQVLTGSCFKLRTVHNIPVTSNKDDDESPGLYGFLH-VIVHSA 772

  Fly    87 MGHLEAEQLLANARDGS--YFVRRSPQSDGYYTLSLRFNKRPKHYKLLYKPGVGHYLRGQDKRFD 149
            .|..::..|.......|  |||.::.      |...|....||                .|:.|:
Human   773 KGFKQSANLYCTLEVDSFGYFVSKAK------TRVFRDTAEPK----------------WDEEFE 815

  Fly   150 TVHDMVADGLINFHMQLHASPIIQQINQQTKNCYQQSPYMTLNGRKLRALSNE-----LGKAAAK 209
                          ::|..|..::.:      ||::....|    |:...:||     :||...:
Human   816 --------------IELEGSQSLRIL------CYEKCYDKT----KVNKDNNEIVDKIMGKGQIQ 856

  Fly   210 ESKESPAEEKEQKQEEPPPPAVDPMPLVYEKPHHFKVHTFKGLNWCEFCANFLWGFTAQGVKCEA 274
                                 :||. .|..|..|..|....|:.     ..|...||::.:..
Human   857 ---------------------LDPQ-TVETKNWHTDVIEMNGIK-----VEFSMKFTSRDMSL-- 892

  Fly   275 CGFVAHSKCSELVPPKCVPDLKRIRGVFGTDLTTMVQLEPHHQIPFVVRRCVEEVEARGMLQEGI 339
                           |..|. |:..||||..::.:.:.| ..::|::||:||||||.||:.:.||
Human   893 ---------------KRTPS-KKQTGVFGVKISVVTKRE-RSKVPYIVRQCVEEVEKRGIEEVGI 940

  Fly   340 YRVSGFADEIEALKLALD--------REGEKTDMSETAYG----------NVNVIAGTLKLYLRL 386
            ||:||.|.:|:|||...|        ...:.....:..|.          ::|.||||||||.|.
Human   941 YRISGVATDIQALKAVFDASKQLQKLTRADSLAQDDPTYNKDILLMLSDMDINAIAGTLKLYFRE 1005

  Fly   387 LPVPLITFQAYPSFMAAGRTGKQAEQRQLMAEAVRRLPPAHHSCLQYMLEHLKRVASHYAVNKMN 451
            ||.||:|.:.||:||........|.:...|...:|.||..:.....::||||||||....:|||:
Human  1006 LPEPLLTDRLYPAFMEGIALSDPAAKENCMMHLLRSLPDPNLITFLFLLEHLKRVAEKEPINKMS 1070

  Fly   452 EHNLATVFAPTL-----IATPQHMTNLTE--------EIFMLSSLITHCKTIFA 492
            .|||||||.|||     :.:..|:|:..:        ::.:|...:.|....||
Human  1071 LHNLATVFGPTLLRPSEVESKAHLTSAADIWSHDVMAQVQVLLYYLQHPPISFA 1124

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP5A	NP_727007.1	SH2_a2chimerin_b2chimerin	75..166	CDD:198215	15/92 (16%)
		C1_1	242..294	CDD:278556	7/51 (14%)
		RhoGAP_chimaerin	302..491	CDD:239837	76/219 (35%)
ABR	XP_016880028.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1094
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940