DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP5A and Myo9a

DIOPT Version :9

Sequence 1:	NP_727007.1	Gene:	RhoGAP5A / 31473	FlyBaseID:	FBgn0029778	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	XP_006511271.1	Gene:	Myo9a / 270163	MGIID:	107735	Length:	2633	Species:	Mus musculus

Alignment Length:	359	Identity:	97/359 - (27%)
Similarity:	165/359 - (45%)	Gaps:	48/359 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   141 LRGQDKRFDTVHDMV-ADGLINFHMQLHAS-------------------PIIQQINQQTKNCYQ- 184
            |..:|.:.||:.|:| ...|..|...:.:|                   .:.:||.::|....|
Mouse  1954 LDNEDSKKDTLVDVVFKKALKEFRQNIFSSYSSALAMDDGKSIRYKDLYALFEQILEKTMRLEQR 2018

  Fly   185 ---QSPY-MTLNGRK--LRALSNELGKAAAKESKESPAEEKEQKQEEPPPPAVDPMPLVYE-KPH 242
               :||. :.:|..|  |....||.....:...|....|.|:::::|        ..||.| ..|
Mouse  2019 DWNESPVRVWVNTFKVFLDEYMNEFKTLDSTAPKVLKTERKKRRKKE--------TDLVEEHNGH 2075

  Fly   243 HFKVHTFKGLNWCEFCANFLWGFTAQGVKCEACGFVAHSKCSELVPPKCV----PDLKRIRGVFG 303
            .||...:....:||:|::.:|......| |:.|.:..|.||......||.    |:|...:  ||
Mouse  2076 IFKATQYSIPTYCEYCSSLIWIMDRASV-CKLCKYACHKKCCLKTTAKCSKKYDPELSSRQ--FG 2137

  Fly   304 TDLTTMVQLEPHHQIPFVVRRCVEEVEARGMLQEGIYRVSGFADEIEALKLALDREGEKTDMSET 368
            .:|:.:...:  ..:|.||.:.:..:|..|:..|||||.||..::|:.|:..||.:.|..::.:.
Mouse  2138 VELSRLTSED--RAVPLVVEKLINYIEMHGLYTEGIYRKSGSTNKIKELRQGLDTDAESVNLDDY 2200

  Fly   369 AYGNVNVIAGTLKLYLRLLPVPLITFQAYPSFMAAGRTGKQAEQRQLMAEAVRRLPPAHHSCLQY 433
               |::|||...|.:||.||.||:||:.|..|:.|....::.|..:.:...:.:|...|.:.|:.
Mouse  2201 ---NIHVIASVFKQWLRDLPNPLMTFELYEEFLRAMGLQERKETIRGVYSVIDQLSRTHLNTLER 2262

  Fly   434 MLEHLKRVASHYAVNKMNEHNLATVFAPTLIATP 467
            ::.||.|:|.....|:|:.:.||.||||.::..|
Mouse  2263 LIFHLVRIALQEDTNRMSANALAIVFAPCILRCP 2296

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP5A	NP_727007.1	SH2_a2chimerin_b2chimerin	75..166	CDD:198215	8/25 (32%)
		C1_1	242..294	CDD:278556	15/55 (27%)
		RhoGAP_chimaerin	302..491	CDD:239837	53/166 (32%)
Myo9a	XP_006511271.1	RA_Myosin-IXa	15..110	CDD:340736
		MYSc_Myo9	160..1006	CDD:276836
		DUF5401	<968..>1283	CDD:375164
		IQ	1117..1138	CDD:197470
		PEHE	<1827..1891	CDD:373705
		C1	2075..2123	CDD:237996	13/48 (27%)
		RhoGAP_myosin_IX	2136..2321	CDD:239842	53/166 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1453
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810