Protein Alignment RhoGAP5A and Myo9b

DIOPT Version :10

• Sequence 1: NP_727007.1
• Gene: RhoGAP5A / 31473
• FlyBaseID: FBgn0029778
• Length: 494
• Species: Drosophila melanogaster
• Sequence 2: XP_063131141.1
• Gene: Myo9b / 25486
• RGDID: 3146
• Length: 2151
• Species: Rattus norvegicus
• Alignment Length: 508
• Identity: 117/508 - (23%)
• Similarity: 200/508 - (39%)
• Gaps: 101/508 - (19%)

  Fly    10 GNANTGGSGGVGGAPEPSSPVQKVWKPELYKLQLEAPAPCPLRCQRTLPLPPAKSTAEAVEANNL 74
            |...|.||||                    :...||||      ::||.:|.::..........|
  Rat  1433 GVEETEGSGG--------------------QAAQEAPA------RKTLDVPSSQQHRHTTGEKPL 1471

  Fly    75 AGRLYGSEYHGLMGHLEAEQ--------LLANARDGSYF------------VRRSPQSDGYYTLS 119
            .|:   ...:..:|.:...:        .:.||.:..:.            .:::|....:...:
  Rat  1472 KGK---KNRNRKVGQITVSEKWRESVFRKITNANELKFLDEFLLNKVNDLRSQKTPIESLFIEAT 1533

  Fly   120 LRFNKRPKHYKLLYKPGVGHYLRGQDKRFDTVHDMVADGLINFHMQLHASPIIQQINQQTKNCYQ 184
            .||.   .:.|.:|....|           .:|....|.:.|:  |:..|.:..:..::..|
  Rat  1534 ERFR---SNIKTMYSVPNG-----------KIHVGYKDLMENY--QIVVSNLAAERGEKDTN--- 1579

  Fly   185 QSPYMTLNGRKLRALSNELGKAAAKES----KESPAEEKEQKQEEPPPPAVDPMPLVYEKPHHFK 245
                :.||  ..::|.:|..::..|..    |:..|::|::|||.    ||..     ...|.|.
  Rat  1580 ----LVLN--VFQSLLDEFTRSYNKTDFEPVKQGKAQKKKRKQER----AVQE-----HNGHVFA 1629

  Fly   246 VHTFKGLNWCEFCANFLWGFTAQGVKCEACGFVAHSKCSELVPPKC------VPDLKRIRGVFGT 304
            .:.......||.|.:::| ...:.:.|..|....|.||...:...|      ..:|....|.||.
  Rat  1630 SYQVNIPQSCEQCLSYIW-LMDKALLCSVCKMTCHKKCVHKIQSYCSYTGRRKSELGAEPGHFGV 1693

  Fly   305 DLTTMVQLEPHHQIPFVVRRCVEEVEARGMLQEGIYRVSGFADEIEALKLALDREGEKTDMSETA 369
            .:.::.  .....:|.|:.:.:|.||..|:..||:||.||.|:....|:.||..:.....:.:..
  Rat  1694 CVDSLT--SDKASVPIVLEKLLEHVEMHGLYTEGLYRKSGAANRTRELRQALQTDPATVKLEDFP 1756

  Fly   370 YGNVNVIAGTLKLYLRLLPVPLITFQAYPSFMAAGRTGKQAEQRQLMAEAVRRLPPAHHSCLQYM 434
               ::.|.|.||.:||.||.||:||..|..|:.|....::.||...:...:..||.|:|:.|:.:
  Rat  1757 ---IHAITGVLKQWLRELPEPLMTFAQYGDFLRAVELPEKQEQLAAIYAVLDHLPEANHTSLERL 1818

  Fly   435 LEHLKRVASHYAVNKMNEHNLATVFAPTLIATPQHMTNLTEEIFMLSSLITHC 487
            :.||.:||....||:|:...||.:|||.|:..|.:...||....:|.  ||.|
  Rat  1819 IFHLVKVALLEDVNRMSPGALAIIFAPCLLRCPDNSDPLTSMKDVLK--ITTC 1869

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP5A	NP_727007.1	SH2_a2chimerin_b2chimerin	75..166	CDD:198215	13/110 (12%)
		C1_CHN	241..293	CDD:410356	12/57 (21%)
		RhoGAP_chimaerin	302..491	CDD:239837	60/186 (32%)
Myo9b	XP_063131141.1	None