DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP5A and Myo9b

DIOPT Version :9

Sequence 1:	NP_727007.1	Gene:	RhoGAP5A / 31473	FlyBaseID:	FBgn0029778	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	XP_038950134.1	Gene:	Myo9b / 25486	RGDID:	3146	Length:	2156	Species:	Rattus norvegicus

Alignment Length:	508	Identity:	117/508 - (23%)
Similarity:	200/508 - (39%)	Gaps:	101/508 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 GNANTGGSGGVGGAPEPSSPVQKVWKPELYKLQLEAPAPCPLRCQRTLPLPPAKSTAEAVEANNL 74
            |...|.||||                    :...||||      ::||.:|.::..........|
  Rat  1438 GVEETEGSGG--------------------QAAQEAPA------RKTLDVPSSQQHRHTTGEKPL 1476

  Fly    75 AGRLYGSEYHGLMGHLEAEQ--------LLANARDGSYF------------VRRSPQSDGYYTLS 119
            .|:   ...:..:|.:...:        .:.||.:..:.            .:::|....:...:
  Rat  1477 KGK---KNRNRKVGQITVSEKWRESVFRKITNANELKFLDEFLLNKVNDLRSQKTPIESLFIEAT 1538

  Fly   120 LRFNKRPKHYKLLYKPGVGHYLRGQDKRFDTVHDMVADGLINFHMQLHASPIIQQINQQTKNCYQ 184
            .||.   .:.|.:|....|           .:|....|.:.|:  |:..|.:..:..::..|
  Rat  1539 ERFR---SNIKTMYSVPNG-----------KIHVGYKDLMENY--QIVVSNLAAERGEKDTN--- 1584

  Fly   185 QSPYMTLNGRKLRALSNELGKAAAKES----KESPAEEKEQKQEEPPPPAVDPMPLVYEKPHHFK 245
                :.||  ..::|.:|..::..|..    |:..|::|::|||.    ||..     ...|.|.
  Rat  1585 ----LVLN--VFQSLLDEFTRSYNKTDFEPVKQGKAQKKKRKQER----AVQE-----HNGHVFA 1634

  Fly   246 VHTFKGLNWCEFCANFLWGFTAQGVKCEACGFVAHSKCSELVPPKC------VPDLKRIRGVFGT 304
            .:.......||.|.:::| ...:.:.|..|....|.||...:...|      ..:|....|.||.
  Rat  1635 SYQVNIPQSCEQCLSYIW-LMDKALLCSVCKMTCHKKCVHKIQSYCSYTGRRKSELGAEPGHFGV 1698

  Fly   305 DLTTMVQLEPHHQIPFVVRRCVEEVEARGMLQEGIYRVSGFADEIEALKLALDREGEKTDMSETA 369
            .:.::.  .....:|.|:.:.:|.||..|:..||:||.||.|:....|:.||..:.....:.:..
  Rat  1699 CVDSLT--SDKASVPIVLEKLLEHVEMHGLYTEGLYRKSGAANRTRELRQALQTDPATVKLEDFP 1761

  Fly   370 YGNVNVIAGTLKLYLRLLPVPLITFQAYPSFMAAGRTGKQAEQRQLMAEAVRRLPPAHHSCLQYM 434
               ::.|.|.||.:||.||.||:||..|..|:.|....::.||...:...:..||.|:|:.|:.:
  Rat  1762 ---IHAITGVLKQWLRELPEPLMTFAQYGDFLRAVELPEKQEQLAAIYAVLDHLPEANHTSLERL 1823

  Fly   435 LEHLKRVASHYAVNKMNEHNLATVFAPTLIATPQHMTNLTEEIFMLSSLITHC 487
            :.||.:||....||:|:...||.:|||.|:..|.:...||....:|.  ||.|
  Rat  1824 IFHLVKVALLEDVNRMSPGALAIIFAPCLLRCPDNSDPLTSMKDVLK--ITTC 1874

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP5A	NP_727007.1	SH2_a2chimerin_b2chimerin	75..166	CDD:198215	13/110 (12%)
		C1_1	242..294	CDD:278556	12/57 (21%)
		RhoGAP_chimaerin	302..491	CDD:239837	60/186 (32%)
Myo9b	XP_038950134.1	Ubiquitin_like_fold	16..112	CDD:421700
		MYSc_Myo9	160..977	CDD:276836
		IQ	1014..1033	CDD:197470
		IQ	1036..1058	CDD:197470
		PTZ00449	<1145..1493	CDD:185628	16/83 (19%)
		C1_Myosin-IXb	1626..1683	CDD:410434	12/62 (19%)
		RhoGAP	1696..1881	CDD:413382	60/186 (32%)
		MCP_Sipho	1941..>2064	CDD:411416
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1453
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810