DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP5A and rga2

DIOPT Version :9

Sequence 1:	NP_727007.1	Gene:	RhoGAP5A / 31473	FlyBaseID:	FBgn0029778	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_594152.1	Gene:	rga2 / 2542682	PomBaseID:	SPAC26A3.09c	Length:	1275	Species:	Schizosaccharomyces pombe

Alignment Length:	200	Identity:	71/200 - (35%)
Similarity:	103/200 - (51%)	Gaps:	16/200 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   297 RIRGVFGTDLTTMVQLEPHHQ---IPFVVRRCVEEVEA-RGMLQEGIYRVSGFADEIEALKLALD 357
            |..|:||..|...|.:.....   :|.||.||:|.:|: |...:|||||:||.|..|:.||...:
pombe  1058 RKSGIFGLPLNEAVNISTQFNDSGLPIVVYRCIEYLESCRAEKEEGIYRLSGSASTIKHLKEQFN 1122

  Fly   358 REGEKTD-MSETAYGNVNVIAGTLKLYLRLLPVPLITFQAYPSFMAAGRTGKQAEQRQLMAEAVR 421
             ||...| :|.....:|:||||.||||||.||..|:....:..|.........:.....:.:.:.
pombe  1123 -EGVDYDLLSSDEEFDVHVIAGLLKLYLRNLPTNLLDTSMHKLFELLPNVPNDSAALGELCDVIS 1186

  Fly   422 RLPPAHHSCLQYMLEHLKRVASHYAVNKMNEHNLATVFAPTLIATPQHMTNLTEEIFMLSSLITH 486
            :|||.:.:.|..:|.||:|:.:...|||||..|:..||:|||        |:..:|||:  ||.:
pombe  1187 KLPPENFALLDSLLHHLRRIIAFEKVNKMNIRNVCIVFSPTL--------NIPSDIFMM--LILN 1241

  Fly   487 CKTIF 491
            ...||
pombe  1242 YDHIF 1246

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP5A	NP_727007.1	SH2_a2chimerin_b2chimerin	75..166	CDD:198215
		C1_1	242..294	CDD:278556
		RhoGAP_chimaerin	302..491	CDD:239837	67/193 (35%)
rga2	NP_594152.1	PH-like	720..833	CDD:302622
		PH	722..836	CDD:278594
		RhoGAP_fBEM3	1062..1249	CDD:239865	68/195 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1094
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940