DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP5A and rga4

DIOPT Version :9

Sequence 1:	NP_727007.1	Gene:	RhoGAP5A / 31473	FlyBaseID:	FBgn0029778	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_595756.1	Gene:	rga4 / 2540593	PomBaseID:	SPBC28E12.03	Length:	933	Species:	Schizosaccharomyces pombe

Alignment Length:	489	Identity:	117/489 - (23%)
Similarity:	194/489 - (39%)	Gaps:	93/489 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 EAVE--ANNLAGRLYGSEYHGLMGH--LEAEQLLANARDGSYFVRRSPQSDGYYTLSL--RFNKR 125
            :|.|  ||.||.|:  ||....:|.  |||..|      .|...:::|.|...:...|  ..|.|
pombe   475 DATEESANELAIRI--SELQAEVGTLLLEATSL------ASIIEQQTPVSPEAFKQELVADLNYR 531

  Fly   126 PKHYKLLYKPGVGHYLRGQD----------KRFDTVHDMVA------DGLINFHMQLHASPIIQQ 174
            ..:.:..::|.:...|..:|          ..:.||.:..|      ..|::.:.||...  :..
pombe   532 LDYLRKSFQPELSTLLLRRDALSTTVSKLQNAYSTVMEETAYLNVKNTELVSLNNQLERE--LAY 594

  Fly   175 INQQTKNCYQQSPYMTLNGRK-----------------LRALSNELG-KAAAKESKESPAEEKEQ 221
            :.:|.......|.:...|..|                 |:.:::.|| :....:.|||....|..
pombe   595 LREQQHKKRTSSSFGIFNNDKKSNRTISTPSPRESFSRLQMVASSLGFRPKDNKDKESGGYNKRN 659

  Fly   222 ---------------KQEEP---PPPAVDPMPLVYEKPHHFKVHTFKGLNWCEFCANFLWGFTAQ 268
                           |::.|   ..|::....|..|:...|    ...:..|:.|..:.....|.
pombe   660 SKIDLKKSFSKRFHWKRDSPHMSSTPSISEEHLASEEQEDF----VPAVGHCKLCGKYSNELRAH 720

  Fly   269 GVKCEACGF--VAHSKCSELVPPKCVPDLKRIRGVFGTDLTTMVQLEPHHQIPFVVRRCVEEVEA 331
            ...|.:...  ...||.||.......||      .|..:..|::      ::|.::..|:..:|:
pombe   721 YQDCVSSTIDRQYQSKKSESPVWALNPD------DFDQNRLTLL------RVPTLIVSCINFIES 773

  Fly   332 RGMLQEGIYRVSGFADEIEALKLALDREGEKTDMSETAYGNVNVIAGTLKLYLRLLPVPLITFQA 396
            .||..||:||.||...:::.:...|..|....|.||    :::.:....|.|||.||.|:||:..
pombe   774 YGMDFEGLYRKSGATSQMKKIVALLRNEDTVLDPSE----DISAVTSVFKQYLRNLPNPIITYDQ 834

  Fly   397 YPSFMAAGRTGKQAEQRQLMAEAVRRLPPAHHSCLQYMLEHLKRVASHYAVNKMNEHNLATVFAP 461
            |..|:.|.......::.......::.|||||...||.::.||.|||::...|:|...|||.||:|
pombe   835 YFPFITAANCASFQDKLDGFIMVIKSLPPAHAEILQLIIRHLARVAAYSHANRMTSKNLAVVFSP 899

  Fly   462 TLIATPQH---MTNLTEEIFMLSSLITHCKTIFA 492
            |||..|.:   :.::|.:.:.|:.||.|...:||
pombe   900 TLIRDPDNSRDVIDMTVKNYSLAFLIDHVHEVFA 933

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP5A	NP_727007.1	SH2_a2chimerin_b2chimerin	75..166	CDD:198215	22/110 (20%)
		C1_1	242..294	CDD:278556	9/53 (17%)
		RhoGAP_chimaerin	302..491	CDD:239837	59/191 (31%)
rga4	NP_595756.1	LIM	24..78	CDD:259829
rga4	NP_595756.1	RhoGAP	759..928	CDD:214618	56/172 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	97	1.000	Domainoid score	I1887
eggNOG	1	0.900	-	-		E1_KOG1453
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001164
OrthoInspector	1	1.000	-	-		mtm9312
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1094
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.840