DRSC/TRiP Functional Genomics Resources

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Protein Alignment RhoGAP5A and Arhgap22

DIOPT Version :10

Sequence 1:NP_727007.1 Gene:RhoGAP5A / 31473 FlyBaseID:FBgn0029778 Length:494 Species:Drosophila melanogaster
Sequence 2:XP_006519017.1 Gene:Arhgap22 / 239027 MGIID:2443418 Length:738 Species:Mus musculus


Alignment Length:247 Identity:77/247 - (31%)
Similarity:123/247 - (49%) Gaps:34/247 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly   253 NWCEFCANFLWGFTAQGVKCEACGFVAHSKCSELVPPKCVPDLKRIRGVFGTDLTTMVQLEPHHQ 317
            :|.:.....:|....:|.          |:.|.:.|.|.:.     .|:||..|...|    ||:
Mouse   161 DWVQAIRRVIWAPLGRGT----------SRSSHVHPVKPLS-----AGIFGQRLEDTV----HHE 206

  Fly   318 -------IPFVVRRCVEEVEARGMLQEGIYRVSGFADEIEALKLALDREGEKTDMSETAYGNVNV 375
                   .|.:|.:||:.:..||:.:||::|:.|.|:.:..|:.:.|. |||.....|.  :|:.
Mouse   207 RKFGPRLAPLLVEQCVDFIRERGLSEEGLFRMPGQANLVRDLQDSFDC-GEKPLFDSTT--DVHT 268

  Fly   376 IAGTLKLYLRLLPVPLITFQAYPSFMAAGR--TGKQAEQRQLMAEAVRRLPPAHHSCLQYMLEHL 438
            :|..||||||.||.|:|.|..|..|::..:  |..:.|....:|:.|..||.|:::.|:|:.:.|
Mouse   269 VASLLKLYLRELPEPVIPFARYEDFLSCAQLLTKDEGEGTVELAKQVSNLPQANYNLLRYICKFL 333

  Fly   439 KRVASHYAVNKMNEHNLATVFAPTLIATPQHMTNLTEEIFMLSSLITHCKTI 490
            ..|.:|..||||:..||||||.|.:: .||....:|  |...:||:.|..|:
Mouse   334 DEVQAHSDVNKMSVQNLATVFGPNIL-RPQIEDPVT--IMEGTSLVQHLMTV 382

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGAP5ANP_727007.1 SH2_a2chimerin_b2chimerin 75..166 CDD:198215
C1_CHN 241..293 CDD:410356 7/39 (18%)
RhoGAP_chimaerin 302..491 CDD:239837 69/198 (35%)
Arhgap22XP_006519017.1 PH-like 62..177 CDD:473070 2/15 (13%)
RhoGAP_ARHGAP22_24_25 193..391 CDD:239855 70/200 (35%)
SMC_prok_B <630..>718 CDD:274008
Blue background indicates that the domain is not in the aligned region.

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