Protein Alignment RhoGAP5A and ARHGAP45

DIOPT Version :9

• Sequence 1: NP_727007.1
• Gene: RhoGAP5A / 31473
• FlyBaseID: FBgn0029778
• Length: 494
• Species: Drosophila melanogaster
• Sequence 2: XP_011526160.1
• Gene: ARHGAP45 / 23526
• HGNCID: 17102
• Length: 1168
• Species: Homo sapiens
• Alignment Length: 532
• Identity: 123/532 - (23%)
• Similarity: 194/532 - (36%)
• Gaps: 193/532 - (36%)

  Fly   106 VRRSPQS------DGYYTLSLRFNKRPKHYKL------LYKPGVGHYLRGQDKRFDTVHDMVADG 158
            :|:|.|:      ..|..:.::....|.|:::      ||.||
Human   499 IRQSDQTIKSATISYYQMMHMQTAPLPVHFQMLCESSKLYDPG---------------------- 541

  Fly   159 LINFHMQLHASPIIQ-QINQQTKNCYQQSPYMTLNG----RKLRALSNELGKAAAKESKESPAEE 218
                  |.:||.:.| |.:|:....|...|:::.|.    .:.|..|..:...|..|:..||.||
Human   542 ------QQYASHVRQLQRDQEPDVHYDFEPHVSANAWSPVMRARKSSFNVSDVARPEAAGSPPEE 600

  Fly   219 ---------KEQKQEEPPPP-----------------------------------------AVDP 233
                     |:.:.|.|..|                                         .:||
Human   601 GGCTEGTPAKDHRGECPAGPRGGRWLPATHPGPSPETPLSPAGRGHQVHKSWPLSISDSDSGLDP 665

  Fly   234 MP------------------------------------------LVYEKP---------HH---- 243
            .|                                          :..|.|         |.
Human   666 GPGAGDFKKFERTSSSGTMSSTEELVDPDGGAGASAFEQADLNGMTPELPVAVPSGPFRHEGLSK 730

  Fly   244 -FKVHTFKGLNW---CEFCANFLWGFTAQGVKCEACGFVAHSKCSELVPPKCVPDLKRIRG---V 301
             .:.|..:.|..   |..|.::::   .||.:||.|....|.||.|.:..:|  ..|:::|   :
Human   731 AARTHRLRKLRTPAKCRECNSYVY---FQGAECEECCLACHKKCLETLAIQC--GHKKLQGRLQL 790

  Fly   302 FGTDLTTMVQLEPHHQIPFVVRRCVEEVEARGMLQEGIYRVSGFADEIEALKLALDREGEKTDMS 366
            ||.|.:...:..| ..:||:|::||.|:|.|.:..:|||||:|....:|.|..|.:...|..::|
Human   791 FGQDFSHAARSAP-DGVPFIVKKCVCEIERRALRTKGIYRVNGVKTRVEKLCQAFENGKELVELS 854

  Fly   367 ETAYGNVNVIAGTLKLYLRLLPVPLITFQAYPSFM--------------AAGRTGKQAEQRQLMA 417
            :   .:.:.|:..||||||.||.|||:|:.|...:              ||.|..:...:.:.:|
Human   855 Q---ASPHDISNVLKLYLRQLPEPLISFRLYHELVGLAKDSLKAEAEAKAASRGRQDGSESEAVA 916

  Fly   418 --------EAVRRLPPAHHSCLQYMLEHLKRVASHYAVNKMNEHNLATVFAPTLIATPQHMTNLT 474
                    |.:|.|||.:.:.|||:|.||:|:......|||...||..||.|||: .|:.    |
Human   917 VALAGRLRELLRDLPPENRASLQYLLRHLRRIVEVEQDNKMTPGNLGIVFGPTLL-RPRP----T 976

  Fly   475 EEIFMLSSLITH 486
            |....||||:.:
Human   977 EATVSLSSLVDY 988

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP5A	NP_727007.1	SH2_a2chimerin_b2chimerin	75..166	CDD:198215	10/71 (14%)
		C1_1	242..294	CDD:278556	15/59 (25%)
		RhoGAP_chimaerin	302..491	CDD:239837	70/207 (34%)
ARHGAP45	XP_011526160.1	FCH	285..360	CDD:214492
		C1	734..779	CDD:197519	13/47 (28%)
		RhoGAP	791..1001	CDD:295372	70/207 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1453
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1300981at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820