DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP5A and Arhgap33

DIOPT Version :9

Sequence 1:	NP_727007.1	Gene:	RhoGAP5A / 31473	FlyBaseID:	FBgn0029778	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_001276611.1	Gene:	Arhgap33 / 233071	MGIID:	2673998	Length:	1305	Species:	Mus musculus

Alignment Length:	365	Identity:	100/365 - (27%)
Similarity:	158/365 - (43%)	Gaps:	64/365 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   181 NCYQQSPYMTL--NGRKLRALSNEL-----GKAAAKESKESPAEEKEQKQEE--------PPPPA 230
            ||.....:|.|  :||:| .||.|.     ..|||...|...|:..::...|        ..||.
Mouse   182 NCGPVLTWMELDNHGRRL-LLSEEASLNIPAVAAAHVVKRYTAQAPDELSFEVGDIVSVIDMPPT 245

  Fly   231 VDPMPLVYEKPHHFKVHTFKGLNWCEFCANFLWGFTAQGVKCEA----CGFVAHSKCSEL---VP 288
            .|..  .:.....|:|..|.     ..|..........|:|.:|    ||..|....|.|   ||
Mouse   246 EDRS--WWRGKRGFQVGFFP-----SECVELFTERPGPGLKADADSPLCGIPAPQGISSLTSAVP 303

  Fly   289 -------------PKCVPDLKRIR-------GVFGTDLTTMVQLEPHHQIPFVVRRCVEEVEARG 333
                         .:..|..:|:|       .|||.||...:. .....:|.|:|.|.|.:||.|
Mouse   304 RPRGKLAGLLRTFMRSRPSRQRLRQRGILRQRVFGCDLGEHLS-NSGQDVPQVLRCCSEFIEAHG 367

  Fly   334 MLQEGIYRVSGFADEIEALKLALDREGEKTDMSETAY-GNVNVIAGTLKLYLRLLPVPLITFQAY 397
            :: :||||:||.:..|:.|:...|.| ...::|..|: .:::.::...|||.|.||.||:|:|.|
Mouse   368 VV-DGIYRLSGVSSNIQRLRHEFDSE-RIPELSGPAFLQDIHSVSSLCKLYFRELPNPLLTYQLY 430

  Fly   398 PSFMAAGRTGKQAEQRQLMAEAVRRLPPAHHSCLQYMLEHLKRVASHYAVNKMNEHNLATVFAPT 462
            ..|..|.....:.|:...:.:.:::|||.|:..|:|:|.||.|:|.|.|...|:..|||.|:||.
Mouse   431 GKFSEAMSVPGEEERLVRVHDVIQQLPPPHYRTLEYLLRHLARMARHSANTSMHARNLAIVWAPN 495

  Fly   463 LIATPQ----------HMTNLTEEIFMLSSLITHCKTIFA 492
            |:.:.:          ....:..:..::..|:||.:.:|:
Mouse   496 LLRSMELESVGLGGAAAFREVRVQSVVVEFLLTHVEVLFS 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP5A	NP_727007.1	SH2_a2chimerin_b2chimerin	75..166	CDD:198215
		C1_1	242..294	CDD:278556	14/71 (20%)
		RhoGAP_chimaerin	302..491	CDD:239837	62/199 (31%)
Arhgap33	NP_001276611.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..64
		PX_domain	80..192	CDD:383026	3/9 (33%)
		SH3_ARHGAP32_33	214..267	CDD:212769	11/59 (19%)
		RhoGAP_CdGAP	335..529	CDD:239849	61/196 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	575..818
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	864..1054
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1115..1305
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1300981at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920