DRSC/TRiP Functional Genomics Resources

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Protein Alignment RhoGAP5A and ARHGAP26

DIOPT Version :9

Sequence 1:NP_727007.1 Gene:RhoGAP5A / 31473 FlyBaseID:FBgn0029778 Length:494 Species:Drosophila melanogaster
Sequence 2:NP_055886.1 Gene:ARHGAP26 / 23092 HGNCID:17073 Length:814 Species:Homo sapiens


Alignment Length:519 Identity:117/519 - (22%)
Similarity:184/519 - (35%) Gaps:148/519 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    60 PPAKSTAEAVEANNLAGRLYGSEYHGLMGHLEAEQLLANARDGSYFVRRSPQSD----GYYTLSL 120
            |..|...|.:.|...|.:.|..|.....|.||....|::.:..|.......|.|    .:|.:||
Human   115 PLEKFRKEQIGAAKEAKKKYDKETEKYCGILEKHLNLSSKKKESQLQEADSQVDLVRQHFYEVSL 179

  Fly   121 RFNKRPKHYKLLYKPGVGHYLRGQDKRFDTVHDMVA--DGLINFHMQLHASPIIQQIN------- 176
            .:..:.:..:             :.|.|:.|..::|  .||..|:.  |...:.:...       
Human   180 EYVFKVQEVQ-------------ERKMFEFVEPLLAFLQGLFTFYH--HGYELAKDFGDFKTQLT 229

  Fly   177 ---QQTKNCYQQSPYMTLNGRKLRALSNELGKAAAKESKESPAEEKEQKQEEPPPPAVDPMPLVY 238
               |.|:|             :.....:|: ::..|:.||:|.|.|...     |..::....|.
Human   230 ISIQNTRN-------------RFEGTRSEV-ESLMKKMKENPLEHKTIS-----PYTMEGYLYVQ 275

  Fly   239 EKPHHFKVHTFKGLNWCEFCANFLWGFTAQGVKCEACGFVAHSKCSELVP--------------- 288
            ||.|.       |.:|.:                ..|.:...||...:||               
Human   276 EKRHF-------GTSWVK----------------HYCTYQRDSKQITMVPFDQKSGGKGGEDESV 317

  Fly   289 --PKCV---PDLKRIRGVFGTD------LTTMVQL---------------EPHH----------- 316
              ..|.   .|....|..|..:      :.||..|               ||.:           
Human   318 ILKSCTRRKTDSIEKRFCFDVEAVDRPGVITMQALSEEDRRLWMEAMDGREPVYNSNKDSQSEGT 382

  Fly   317 ----QIPF-VVRRCVEEVEARGMLQEGIYRVSGFADEIEALKLAL--DREGEKTDMSETAYGNVN 374
                .|.| ::|:|:..||.||:.::|:||:.|....::.|...|  .:...:|:....|...:.
Human   383 AQLDSIGFSIIRKCIHAVETRGINEQGLYRIVGVNSRVQKLLSVLMDPKTASETETDICAEWEIK 447

  Fly   375 VIAGTLKLYLRLLPVPLITFQAYPSFMAAGRTGKQAEQRQLMAEAVRRLPPAHHSCLQYMLEHLK 439
            .|...||.|||:||.||:.:|...||:.|.:...|..:...:...|.|||..:...||.::.||.
Human   448 TITSALKTYLRMLPGPLMMYQFQRSFIKAAKLENQESRVSEIHSLVHRLPEKNRQMLQLLMNHLA 512

  Fly   440 RVASHYAVNKMNEHNLATVFAPTLIATPQHMT----------NLTEEIFMLSSLITHCKTIFAT 493
            .||:::..|.|...||..||.|||: .||..|          |:..||     ||.:.:.||.|
Human   513 NVANNHKQNLMTVANLGVVFGPTLL-RPQEETVAAIMDIKFQNIVIEI-----LIENHEKIFNT 570

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGAP5ANP_727007.1 SH2_a2chimerin_b2chimerin 75..166 CDD:198215 20/96 (21%)
C1_1 242..294 CDD:278556 9/71 (13%)
RhoGAP_chimaerin 302..491 CDD:239837 64/237 (27%)
ARHGAP26NP_055886.1 BAR_GRAF 19..225 CDD:153320 25/124 (20%)
BAR-PH_GRAF_family 267..371 CDD:269953 20/126 (16%)
PH 267..364 CDD:278594 18/119 (15%)
RhoGAP_Graf 364..563 CDD:239839 60/204 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 624..696
SH3_GRAF 759..814 CDD:212997
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1094
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.940

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