DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP5A and Arhgap9

DIOPT Version :9

Sequence 1:	NP_727007.1	Gene:	RhoGAP5A / 31473	FlyBaseID:	FBgn0029778	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_001272714.1	Gene:	Arhgap9 / 216445	MGIID:	2143764	Length:	648	Species:	Mus musculus

Alignment Length:	237	Identity:	74/237 - (31%)
Similarity:	115/237 - (48%)	Gaps:	27/237 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   281 SKCSELVPPKCVPDLKRI--RG-----VFGTDLTTMVQLEPHHQIPFVVRRCVEEVEARGMLQEG 338
            :|...|:..:  |.|:.:  ||     |||..|.::.|.| ...:|..||.|||.|:.:|:..:|
Mouse   412 NKLKRLIAKR--PTLQSLQERGLFRDQVFGCQLESLCQRE-GDTVPSFVRLCVEAVDKKGLDVDG 473

  Fly   339 IYRVSGFADEIEALKLALDRE---------------GE--KTDMSETAYGNVNVIAGTLKLYLRL 386
            ||||||....::.|:..:|||               |:  |.|:....:.:::|:.|.|||:.|.
Mouse   474 IYRVSGNLAVVQKLRFLVDRERAVTSDGRYMFPEQAGQEGKLDLDSAEWDDIHVVTGALKLFFRE 538

  Fly   387 LPVPLITFQAYPSFMAAGRTGKQAEQRQLMAEAVRRLPPAHHSCLQYMLEHLKRVASHYAVNKMN 451
            ||.||:.....|.|..|....:..:....:.:.:..||..:|..|:|:||||.||.:|...|:|.
Mouse   539 LPQPLVPALLLPDFRDALELSEPEQCLSKIQKLIDSLPRPNHDTLKYILEHLCRVIAHSDKNRMT 603

  Fly   452 EHNLATVFAPTLIATPQHMTNLTEEIFMLSSLITHCKTIFAT 493
            .|||..||.|||....|..:::...:|....|:......||:
Mouse   604 AHNLGIVFGPTLFRPEQEASDMAAHVFYPGQLVQLMLNNFAS 645

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP5A	NP_727007.1	SH2_a2chimerin_b2chimerin	75..166	CDD:198215
		C1_1	242..294	CDD:278556	2/12 (17%)
		RhoGAP_chimaerin	302..491	CDD:239837	65/205 (32%)
Arhgap9	NP_001272714.1	SH3	26..82	CDD:302595
		PH_ARHGAP9-like	236..349	CDD:270053
		PH	250..348	CDD:278594
		ASCH	<346..432	CDD:294653	5/21 (24%)
		RhoGAP_ARHGAP27_15_12_9	438..642	CDD:239868	65/204 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1300981at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920