DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP5A and Syde2

DIOPT Version :9

Sequence 1:	NP_727007.1	Gene:	RhoGAP5A / 31473	FlyBaseID:	FBgn0029778	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	XP_006501355.3	Gene:	Syde2 / 214804	MGIID:	3036264	Length:	1315	Species:	Mus musculus

Alignment Length:	196	Identity:	64/196 - (32%)
Similarity:	101/196 - (51%)	Gaps:	11/196 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   294 DLKRIRGVFGTDLTTMVQLE-PHHQIPFVVRRCVEEVEARGMLQEGIYRVSGFADEIEALKLALD 357
            |..|...:||.|:..:|:.| ....:|.::::|:.|:|.||....|:||:.|.|...:.|:.|.:
Mouse   928 DKNREAVMFGVDIQKVVEKENVGLMVPLLIQKCIVEIEKRGCQVVGLYRLCGSAAVKKELREAFE 992

  Fly   358 REGEKTDMSETAYGNVNVIAGTLKLYLRLLPVPLITFQAY----------PSFMAAGRTGKQAEQ 412
            ::.:...:.|..|.::|||.|.||.|||.||.||||.|.|          |..|::.....:...
Mouse   993 KDSKTVGLCENQYPDINVITGVLKDYLRELPSPLITKQLYEAVLDAMAKSPLKMSSSGCENEPSD 1057

  Fly   413 RQLMAEAVRRLPPAHHSCLQYMLEHLKRVASHYAVNKMNEHNLATVFAPTLIATPQHMTNLTEEI 477
            .:|..:.:..||....:.|:.:|:|||.|||::.||||...|||..|.|.|:...|..:.....:
Mouse  1058 SRLTVDLLDCLPDVEKATLKMLLDHLKLVASYHEVNKMTCQNLAVCFGPVLLNQRQEASTHNNRV 1122

  Fly   478 F 478
            |
Mouse  1123 F 1123

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP5A	NP_727007.1	SH2_a2chimerin_b2chimerin	75..166	CDD:198215
		C1_1	242..294	CDD:278556	64/196 (33%)
		RhoGAP_chimaerin	302..491	CDD:239837	62/188 (33%)
Syde2	XP_006501355.3	PHA03379	<109..>326	CDD:223066
		C2	801..916	CDD:387358
		RhoGAP	936..1150	CDD:383032	62/188 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1300981at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920