Protein Alignment RhoGAP5A and Arhgap29

DIOPT Version :9

• Sequence 1: NP_727007.1
• Gene: RhoGAP5A / 31473
• FlyBaseID: FBgn0029778
• Length: 494
• Species: Drosophila melanogaster
• Sequence 2: NP_001343453.1
• Gene: Arhgap29 / 214137
• MGIID: 2443818
• Length: 1266
• Species: Mus musculus
• Alignment Length: 488
• Identity: 129/488 - (26%)
• Similarity: 199/488 - (40%)
• Gaps: 97/488 - (19%)

  Fly    62 AKSTAEAVEANNLAGRLY--GSEYHGLMGHLEAEQLLANARDGSY--FVRRSPQSDGYYTL-SLR 121
            |.|.|.::::...:.:||  |.||...:....:.:|.... ||:.  .:..|||:.||... ||.
Mouse   440 AASLANSLQSLCDSAKLYDPGQEYSEFVKATSSSELEEKV-DGNVNKQMTNSPQTSGYEPADSLE 503

  Fly   122 FNKRPKHYKLLYKPGVGHYLRGQDKRFDTVHDMVADGLI---NFHMQLHASPIIQQINQQTKNCY 183
            ...|        .|...|.|  ::.|.....||.....:   .|.|                  :
Mouse   504 DVAR--------LPDSCHKL--EEDRCSNSADMTGPSFVRSWKFGM------------------F 540

  Fly   184 QQSPYMTLNGRKLRALSNEL-------GKAAAKESKESPAEEKEQKQEEPPPPA-VDPMPL-VYE 239
            ..|. .|....:.|:|.:|.       .|.....|..:.:...:..:.|||.|: ..|..| .::
Mouse   541 SDSE-STGGSSESRSLDSESISPGDFHRKLPRTPSSGTMSSADDLDEREPPSPSEAGPNSLGAFK 604

  Fly   240 KPHHFK---VHTFKGL---NWCEFCANFLWGFTAQGVKCEACGFVAHSKCSELVPPKCVPDLKRI 298
            |....|   .|.|:.|   ..|..|...:   ...||:||.|..|.|.||.|.:...|  ..:::
Mouse   605 KTLMSKAALTHKFRKLRSPTKCRDCDGIV---MFPGVECEECLLVCHRKCLENLVIIC--GHQKL 664

  Fly   299 RG---VFGTDLTTMVQLEPHHQIPFVVRRCVEEVEARGMLQEGIYRVSGFADEIEALKLALDREG 360
            :|   :||.:...:.:.|| ..||||::.|..|:|.|.:..:|||||.|...:.|.|..||:...
Mouse   665 QGKMHIFGAEFIQVAKKEP-DGIPFVLKICASEIENRALCLQGIYRVCGNKIKTEKLCQALENGM 728

  Fly   361 EKTDMSETAYGNVNVIAGTLKLYLRLLPVPLITFQAYPSFMAAGRTGKQAEQRQ----------- 414
            ...|:||.:..:   |...||||||.||.|.|.|:.|..|:...:..:...:.|
Mouse   729 HLVDISEFSSHD---ICDVLKLYLRQLPEPFILFRLYKEFIDLAKEIQHVNEEQEAKKDSPEDKK 790

  Fly   415 -------------LMAEAVRRLPPAHHSCLQYMLEHLKRVASHYAVNKMNEHNLATVFAPTLI-- 464
                         ...:.:|:||.:|.:.|.|::.||:||..|...||||..||..:|.||||
Mouse   791 HPHVSIEVNRILLKSKDLLRQLPASHFNSLHYLIAHLRRVVDHAEENKMNSKNLGVIFGPTLIRP 855

  Fly   465 ---ATPQHMTNLTE---EIFMLSSLITHCKTIF 491
               ..|..:::|.|   :..::..|||:.:.||
Mouse   856 RPTTAPVTISSLAEYSNQARLVEFLITYSQKIF 888

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP5A	NP_727007.1	SH2_a2chimerin_b2chimerin	75..166	CDD:198215	24/98 (24%)
		C1_1	242..294	CDD:278556	17/57 (30%)
		RhoGAP_chimaerin	302..491	CDD:239837	68/220 (31%)
Arhgap29	NP_001343453.1	BAR	220..436	CDD:325158
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	482..501		5/18 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	542..601		12/59 (20%)
		C1	614..659	CDD:197519	15/47 (32%)
		RhoGAP	671..883	CDD:295372	67/215 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1039..1081
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1116..1157
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1209..1266
		Interaction with PTPN13/PTPL1. /evidence=ECO:0000250	1263..1266

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1453
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1300981at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1094
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.850