Protein Alignment RhoGAP5A and Myo9b

DIOPT Version :9

• Sequence 1: NP_727007.1
• Gene: RhoGAP5A / 31473
• FlyBaseID: FBgn0029778
• Length: 494
• Species: Drosophila melanogaster
• Sequence 2: XP_006509629.1
• Gene: Myo9b / 17925
• MGIID: 106624
• Length: 2164
• Species: Mus musculus
• Alignment Length: 528
• Identity: 119/528 - (22%)
• Similarity: 212/528 - (40%)
• Gaps: 100/528 - (18%)

  Fly     9 AGNANTGGSGGV--GGAPEPSSPVQKVW-------KPELYKLQ----------LEAPAPCPLRCQ 54
            :|:.:.|...|:  |...:..|..::::       ||.|..::          .|.||      :
Mouse  1408 SGDPSAGPDAGLSPGSQGDSKSAFKRLFLHKAKDKKPSLEGVEETESNGGQAAQETPA------R 1466

  Fly    55 RTLPLPPAKSTAEAVEANNLAGRLYGSEYHGLMGHLEAEQ--------LLANARDGSYF------ 105
            :||.:|.::..........|.|:   ...:..:|.:...:        .:.||.:..:.
Mouse  1467 KTLDVPSSQQHRHTTGEKPLKGK---KNRNRKVGQITVSEKWRESVFRKITNANELKFLDEFLLN 1528

  Fly   106 ------VRRSPQSDGYYTLSLRFNKRPKHYKLLYKPGVGHYLRGQDKRFDTVHDMVADGLINFHM 164
                  .:::|....:...:.||.   .:.|.:|....|           .:|....|.:.|:
Mouse  1529 KVNDLRSQKTPIESLFIEATERFR---SNIKTMYSVPNG-----------KIHVGYKDLMENY-- 1577

  Fly   165 QLHASPIIQQINQQTKNCYQQSPYMTLNGRKLRALSNEL----GKAAAKESKESPAEEKEQKQEE 225
            |:..|.:..:..::..|       :.||  ..::|.:|.    .|...:.:|:|.|::|::|||.
Mouse  1578 QIVVSNLAAERGEKDTN-------LVLN--VFQSLLDEFTRSYNKTDFERAKQSKAQKKKRKQER 1633

  Fly   226 PPPPAVDPMPLVYEKPHHFKVHTFKGLNWCEFCANFLWGFTAQGVKCEACGFVAHSKCSELVPPK 290
                ||..     ...|.|..:.......||.|.:::| ...:.:.|..|....|.||...:...
Mouse  1634 ----AVQE-----HNGHVFASYQVNIPQSCEQCLSYIW-LMDKALLCSVCKMTCHKKCVHKIQSY 1688

  Fly   291 C------VPDLKRIRGVFGTDLTTMVQLEPHHQIPFVVRRCVEEVEARGMLQEGIYRVSGFADEI 349
            |      ..:|....|.||..:.::.  .....:|.|:.:.:|.||..|:..||:||.||.|:..
Mouse  1689 CSYTGRRKSELGAEPGHFGVCVDSLT--SDKASVPIVLEKLLEHVEMHGLYTEGLYRKSGAANRT 1751

  Fly   350 EALKLALDREGEKTDMSETAYGNVNVIAGTLKLYLRLLPVPLITFQAYPSFMAAGRTGKQAEQRQ 414
            ..|:.||..:.....:.:..   ::.|.|.||.:||.||.||:||..|..|:.|....::.||..
Mouse  1752 RELRQALQTDPAAVKLEDFP---IHAITGVLKQWLRELPEPLMTFAQYGDFLRAVELPEKQEQLS 1813

  Fly   415 LMAEAVRRLPPAHHSCLQYMLEHLKRVASHYAVNKMNEHNLATVFAPTLIATPQHMTNLTEEIFM 479
            .:...:..||.|:|:.|:.::.||.:||....||:|:...||.:|||.|:..|.:...||....:
Mouse  1814 AIYAVLDHLPEANHTSLERLIFHLVKVALLEDVNRMSPGALAIIFAPCLLRCPDNSDPLTSMKDV 1878

  Fly   480 LSSLITHC 487
            |.  ||.|
Mouse  1879 LK--ITTC 1884

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP5A	NP_727007.1	SH2_a2chimerin_b2chimerin	75..166	CDD:198215	13/110 (12%)
		C1_1	242..294	CDD:278556	12/57 (21%)
		RhoGAP_chimaerin	302..491	CDD:239837	60/186 (32%)
Myo9b	XP_006509629.1	RA_Myosin-IXb	16..112	CDD:340737
		MYSc_Myo9	160..977	CDD:276836
		IQ	1014..1035	CDD:197470
		IQ	1036..1058	CDD:197470
		DUF4045	1207..>1495	CDD:372533	16/95 (17%)
		C1	1641..1689	CDD:237996	11/48 (23%)
		RhoGAP_myosin_IXB	1706..1891	CDD:239872	60/186 (32%)
		PHA02682	<2029..>2123	CDD:177464

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1453
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810