DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP5A and rga-3

DIOPT Version :9

Sequence 1:	NP_727007.1	Gene:	RhoGAP5A / 31473	FlyBaseID:	FBgn0029778	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_504503.1	Gene:	rga-3 / 178961	WormBaseID:	WBGene00019600	Length:	1085	Species:	Caenorhabditis elegans

Alignment Length:	199	Identity:	48/199 - (24%)
Similarity:	84/199 - (42%)	Gaps:	40/199 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   308 TMVQLEPHHQIPFVVRRCVEEVEARGMLQEGIYRVSGFADEIEALKLALDREGEKTDMSETAYGN 372
            |.::|:   ::|..:......:...||..:||:|..|.:..:...::....:|::...::  |..
Worm    58 TRIRLK---EVPKFIVNAFNIISKHGMDTDGIFRKEGNSVRLNRAEVQAIYKGQRDIPND--YSV 117

  Fly   373 VNVIAGTLKLYLRLLPVPLITFQAYPSFMAAGRTGKQAEQ----------RQLMAE-------AV 420
            ::|.. .:|.:||.|..||:     .|.....|..|:|.|          |..||:       .:
Worm   118 IDVCT-MVKRFLRDLKPPLL-----DSEECRARLLKKACQARISDGFLMTRDEMADVFYMEDRTI 176

  Fly   421 RRLPP----AHHSCLQYMLEHLKRVASHYAVNKMNEHNLATVFAPTLIA--------TPQHMTNL 473
            .:..|    ||.|.|.|::..|.|:|:|...:||:..|||.||..::..        |||.....
Worm   177 EQQTPLLSDAHASTLGYVMRQLNRIAAHSEQHKMSIENLAIVFIGSVFGDGIHDSKKTPQLRRGS 241

  Fly   474 TEEI 477
            .|:|
Worm   242 KEDI 245

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP5A	NP_727007.1	SH2_a2chimerin_b2chimerin	75..166	CDD:198215
		C1_1	242..294	CDD:278556
		RhoGAP_chimaerin	302..491	CDD:239837	48/199 (24%)
rga-3	NP_504503.1	RhoGAP	63..232	CDD:214618	41/179 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1453
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900