DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP5A and T04C9.1

DIOPT Version :9

Sequence 1:	NP_727007.1	Gene:	RhoGAP5A / 31473	FlyBaseID:	FBgn0029778	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_741163.2	Gene:	T04C9.1 / 175849	WormBaseID:	WBGene00020209	Length:	881	Species:	Caenorhabditis elegans

Alignment Length:	192	Identity:	56/192 - (29%)
Similarity:	91/192 - (47%)	Gaps:	36/192 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   322 VRRCVEEVEARGMLQEGIYRVSGFADEIE-ALKLALDRE--GEKTDMSETAYGNVNV-------- 375
            |::|::.:|..|:.::|:||..|...::: .:.|.|||.  .||        |.:|:
Worm   413 VQQCIDILEESGIHEQGVYRNCGVTSKVQKMMMLGLDRRKASEK--------GGLNLRDDEWETK 469

  Fly   376 -IAGTLKLYLRLLPVPLITFQAYPSFMAAGRTGKQAEQRQLMAEAVRRLPPAHHSCLQYMLEHLK 439
             |:..:|.:||.||.||:||:.:..|:.|.:.|....:...:...|.:||..|...|:.::.|||
Worm   470 TISSAVKTFLRNLPEPLMTFELHNVFINAAKMGDATMRIDHIHFYVHQLPAQHLRMLEIVVRHLK 534

  Fly   440 RVASHYAVNKMNEHNLATVFAPTLIATPQHMT----------NLTEEIFMLSSLITHCKTIF 491
            |||.....|.|...||...|.|||: .|:..|          |:..|:     ||::...||
Worm   535 RVADLSNENLMTVSNLGVCFGPTLL-RPKEETVAAIMDIKFCNVVVEV-----LISNYDKIF 590

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP5A	NP_727007.1	SH2_a2chimerin_b2chimerin	75..166	CDD:198215
		C1_1	242..294	CDD:278556
		RhoGAP_chimaerin	302..491	CDD:239837	54/190 (28%)
T04C9.1	NP_741163.2	BAR_RhoGAP_OPHN1-like	19..225	CDD:153286
		BAR-PH_GRAF_family	271..388	CDD:269953
		RhoGAP	381..585	CDD:295372	54/185 (29%)
		SH3_GRAF-like	826..879	CDD:212815
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1300981at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1094
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.950