Protein Alignment RhoGAP5A and chin-1

DIOPT Version :10

• Sequence 1: NP_727007.1
• Gene: RhoGAP5A / 31473
• FlyBaseID: FBgn0029778
• Length: 494
• Species: Drosophila melanogaster
• Sequence 2: NP_497323.3
• Gene: chin-1 / 175268
• WormBaseID: WBGene00015267
• Length: 421
• Species: Caenorhabditis elegans
• Alignment Length: 480
• Identity: 167/480 - (34%)
• Similarity: 242/480 - (50%)
• Gaps: 78/480 - (16%)

  Fly    22 GAPEPSSPVQKVWKPELYKLQLEAPAPCPLRCQRTLPLPPAKSTAEAVEANNLAGRLYGSEYHGL 86
            |.|..|...:..||..||.||.:||.|..:.|::.|...|               |.:|:|:|||
 Worm     5 GPPGSSGASKGYWKQNLYLLQEKAPKPNAVLCRKPLQQRP---------------RHFGAEFHGL 54

  Fly    87 MGHLEAEQLLANARDGSYFVRRSPQSDGYYTLSLRFNKRPKHYKLLYKPGVGHYLRGQDKRFDTV 151
            :...|||::|..|.:|||.||.|.:|....||.:.|:.:..:|||.|.   |.:..| :|||||:
 Worm    55 IDRNEAEKMLLEAGEGSYLVRESNRSRDACTLCMIFDAKVMNYKLYYD---GQFYVG-EKRFDTM 115

  Fly   152 HDMVADGLINFHMQLHASPIIQQINQQTKNCYQQSPYMTLNGRKLRALSNELGKAAAKESKESPA 216
            ..:||||||:..:.|||:..|:::..:.  .|:.|||            :....|||..|
 Worm   116 DLLVADGLISMFVDLHAADYIKRMADEA--IYEDSPY------------SRYTNAAATTS----- 161

  Fly   217 EEKEQKQEEPPPPAVDPMPLVYEKPHHFKVHTFKGLNWCEFCANFLWGFTAQGVKCEACGFVAHS 281
                           |.:.....:.|:|..:|||..::|::|.|||||...||::||.|||.||.
 Worm   162 ---------------DIVRRPVTRAHNFTSYTFKAPHYCDYCRNFLWGLVHQGMRCEDCGFAAHK 211

  Fly   282 KCSELVPPKCVPDLKRIRGVFGTDLTTMVQLEPHH--QIPFVVRRCVEEVEARGMLQEGIYRVSG 344
            ||||.....||||.|.::.:||.|:||:...   |  .:|.:|..|:.|||:||:..||||||||
 Worm   212 KCSEKTLHDCVPDSKYVKRMFGVDITTLCMA---HGADLPPIVPLCIGEVESRGLDVEGIYRVSG 273

  Fly   345 FADEIEALKLALDREGEKTDMSETAYGNVNVIAGTLKLYLRLLPVPLITFQAYPSFMAAGRTGKQ 409
            ..|.:|.||...| ..:..|::...  :::.:.|.||||.||||..||.|..:...:.|.:...|
 Worm   274 SYDHMEKLKQQFD-SNQYVDLATVC--DIHTVCGLLKLYFRLLPQQLIPFSVHKQLLVAYQETNQ 335

  Fly   410 A---EQRQLMAEAVRRLPPAHHSCLQYMLEHLKRVASHYAVNKMNEHNLATVFAPTLI------A 465
            .   |:.:.:.:.:..|..|:...|..:|.|||:||.|.|.|||...||||:|:|||.      |
 Worm   336 RSTHERERQIRKVMMELSDANIITLGAVLAHLKKVADHSAKNKMTVENLATIFSPTLFCSGSIPA 400

  Fly   466 TPQHMTNLTEEIFMLSSLITHCKTI 490
            .|.|.        :|..||.:.:.:
 Worm   401 MPNHQ--------LLHFLINNPRVV 417

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP5A	NP_727007.1	SH2_a2chimerin_b2chimerin	75..166	CDD:198215	38/90 (42%)
		C1_CHN	241..293	CDD:410356	26/51 (51%)
		RhoGAP_chimaerin	302..491	CDD:239837	71/200 (36%)
chin-1	NP_497323.3	SH2_a2chimerin_b2chimerin	43..130	CDD:198215	39/105 (37%)
		C1_CHN	171..223	CDD:410356	26/51 (51%)
		RhoGAP	248..413	CDD:238090	65/175 (37%)