DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP5A and spv-1

DIOPT Version :9

Sequence 1:	NP_727007.1	Gene:	RhoGAP5A / 31473	FlyBaseID:	FBgn0029778	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_495666.4	Gene:	spv-1 / 174278	WormBaseID:	WBGene00014051	Length:	966	Species:	Caenorhabditis elegans

Alignment Length:	269	Identity:	77/269 - (28%)
Similarity:	128/269 - (47%)	Gaps:	39/269 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   242 HHFK--VHTFKGLNWCEFCANFLWGFTAQGVKCEACGFVAHSKCSELVPPKCVPDLK---RIRGV 301
            ||.:  |...|    |..|......:|   |:|..||...|..|...:...|....|   |...:
Worm   539 HHIQRTVQPSK----CSACDTLSILYT---VQCIDCGGQWHKACFPRIQQVCGQAAKLVDRRTSI 596

  Fly   302 FGTDLTTMVQLEPHHQIPFVVRRCVEEVEARGMLQEGIYRVSGFADEIEALKLALDREGEKTDMS 366
            ||..|..:::.:..| ||.::.:.:::::.||:..:||||..|...:||.:..|.:|....   .
Worm   597 FGVPLKGLLEHQNRH-IPLIIEKSIDQLQRRGLRAKGIYRTCGVKSKIEEICNAFERSSSD---D 657

  Fly   367 ETAYGNVNV--IAGTLKLYLRLLPVPLITFQAYPSFMAAG-------RTGKQAEQRQL--MAEAV 420
            |....|.|.  :|..:|||||.||.||:||:.|..|:..|       .:|...|:.::  :.:..
Worm   658 EVCLDNENPMNLASVVKLYLRKLPEPLLTFELYDDFVRLGTECCSAQASGSNCEEERVEQLRQLA 722

  Fly   421 RRLPPAHHSCLQYMLEHLKRVASHYAVNKMNEHNLATVFAPTLI-ATPQHM-----------TNL 473
            |:||..::..|::::.||.||:..:.||.|:..||:||.||:|| .:|:.:           ||.
Worm   723 RKLPVHNYETLKFIMLHLNRVSWFHEVNLMSTSNLSTVIAPSLIWMSPKRIDHTSAIMHTQYTNK 787

  Fly   474 TEEIFMLSS 482
            ..|:.:.:|
Worm   788 AIEVMIRNS 796

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP5A	NP_727007.1	SH2_a2chimerin_b2chimerin	75..166	CDD:198215
		C1_1	242..294	CDD:278556	14/53 (26%)
		RhoGAP_chimaerin	302..491	CDD:239837	61/204 (30%)
spv-1	NP_495666.4	FCH	195..278	CDD:214492
		C1	537..583	CDD:197519	13/50 (26%)
		RhoGAP	610..796	CDD:214618	57/189 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1300981at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1094
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.950