DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP5A and ARHGAP42

DIOPT Version :9

Sequence 1:	NP_727007.1	Gene:	RhoGAP5A / 31473	FlyBaseID:	FBgn0029778	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_689645.2	Gene:	ARHGAP42 / 143872	HGNCID:	26545	Length:	874	Species:	Homo sapiens

Alignment Length:	580	Identity:	126/580 - (21%)
Similarity:	220/580 - (37%)	Gaps:	148/580 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 GSGGVGGAPEPSSPVQKVWKPELYKLQLEAPAPCPLRCQRTLPLPPAKSTAE------AVEANNL 74
            ||..:|.....|..||| :...|...|.|    |....:....:..|:|..|      |||...
Human    43 GSLLIGALRNLSMAVQK-FSQSLQDFQFE----CIGDAETDDEISIAQSLKEFARLLIAVEEER- 101

  Fly    75 AGRLYGSEYHGLMGHLE---AEQLLANARDGSYFVRRSPQSDGYYT-----LSLRFNKRPKH--- 128
             .||..:....|:..||   .||:.| |:||.  .:...:|:.||:     |:|...|:..|
Human   102 -RRLIQNANDVLIAPLEKFRKEQIGA-AKDGK--KKFDKESEKYYSILEKHLNLSAKKKESHLQE 162

  Fly   129 --------YKLLYKPGVGHYLRGQD----KRFDTVHDMVA--DGLINFH-----MQLHASPIIQQ 174
                    ::..|:..:.:..:.|:    |:|:.|..:::  .||..|:     :....:|..||
Human   163 ADTQIDREHQNFYEASLEYVFKIQEVQEKKKFEFVEPLLSFLQGLFTFYHEGYELAQEFAPYKQQ 227

  Fly   175 IN---QQTKNCYQQSPYMTLNGRKLRALSNELGKAAAKESKESPAEEKEQKQEEPPPP--AVDPM 234
            :.   |.|:|.::                     :..:|.:......|...|:..||.  .::..
Human   228 LQFNLQNTRNNFE---------------------STRQEVERLMQRMKSANQDYRPPSQWTMEGY 271

  Fly   235 PLVYEK-PHHFKVHTFKGLNWCEFCANFLWG---FTAQGVKCEACGFVAHSKCSELVPPKCVPDL 295
            ..|.|| |        .|..|.:....:..|   ||....:.::.|     |.:.||...  |::
Human   272 LYVQEKRP--------LGFTWIKHYCTYDKGSKTFTMSVSEMKSSG-----KMNGLVTSS--PEM 321

  Fly   296 KRIRGVF--GTD--------------------------------LTTMVQLEPHHQIPFV----- 321
            .:::...  .||                                |..|...||.:.:|.:
Human   322 FKLKSCIRRKTDSIDKRFCFDIEVVERHGIITLQAFSEANRKLWLEAMDGKEPIYTLPAIISKKE 386

  Fly   322 -----------VRRCVEEVEARGMLQEGIYRVSGFADEIEALKLAL--DREGEKTDMSETAYGNV 373
                       ||:|::.||.||:...|:||:.|...:::.|....  .:.....|:....:.|.
Human   387 EMYLNEAGFNFVRKCIQAVETRGITILGLYRIGGVNSKVQKLMNTTFSPKSPPDIDIDIELWDNK 451

  Fly   374 NVIAGTLKLYLRLLPVPLITFQAYPSFMAAGRTGKQAEQRQLMAEAVRRLPPAHHSCLQYMLEHL 438
            .:.:| ||.|||.|..||:|::.:..|:.|.::..|..:.:.:...|.:||..:...|..:::||
Human   452 TITSG-LKNYLRCLAEPLMTYKLHKDFIIAVKSDDQNYRVEAVHALVHKLPEKNREMLDILIKHL 515

  Fly   439 KRVASHYAVNKMNEHNLATVFAPTLIATPQH----MTNLTEEIFMLSSLITHCKTIFATS 494
            .:|:.|...|.|...||..:|.|||:...:.    |.|:..:..::..||.|.:.||.|:
Human   516 VKVSLHSQQNLMTVSNLGVIFGPTLMRAQEETVAAMMNIKFQNIVVEILIEHYEKIFHTA 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP5A	NP_727007.1	SH2_a2chimerin_b2chimerin	75..166	CDD:198215	26/120 (22%)
		C1_1	242..294	CDD:278556	9/54 (17%)
		RhoGAP_chimaerin	302..491	CDD:239837	55/244 (23%)
ARHGAP42	NP_689645.2	BAR_GAP10-like	19..225	CDD:153318	44/191 (23%)
		BAR-PH_GRAF_family	267..376	CDD:269953	20/123 (16%)
		RhoGAP_Graf	369..567	CDD:239839	51/198 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	575..720		0/1 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	749..777
		SH3_GRAF3	820..874	CDD:212999
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1094
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940