Protein Alignment RhoGAP5A and Rlip

DIOPT Version :10

• Sequence 1: NP_727007.1
• Gene: RhoGAP5A / 31473
• FlyBaseID: FBgn0029778
• Length: 494
• Species: Drosophila melanogaster
• Sequence 2: XP_312836.6
• Gene: Rlip / 1273818
• VectorBaseID: AGAMI1_005099
• Length: 687
• Species: Anopheles gambiae
• Alignment Length: 460
• Identity: 101/460 - (21%)
• Similarity: 170/460 - (36%)
• Gaps: 112/460 - (24%)

  Fly    46 PAPCPLRCQRTLPLPPAKSTAEAVEANNLAGRLYGSEYHGLMGHLEAEQLLANARDGSYFVRRSP 110
            |...|:.|:..:..    .:.:.|| .:..| ||||:..|           .:.:|...|....|
Mosquito    19 PDQFPVVCKVAMDF----DSPDCVE-KDFPG-LYGSDASG-----------KSKKDDKDFSDADP 66

  Fly   111 QSDGYYTLSLRFNKRPKHYKLLYKPGVGHYLRGQDKRFDTVHDMVADGLINFHMQLHASPIIQQI 175
            :......|.:...|..|..|..|..     |.|:                       :||   :.
Mosquito    67 EKVSKKELLIGRRKDKKEKKTAYAT-----LEGE-----------------------SSP---EE 100

  Fly   176 NQQTKNCYQQSPYMTLNGR--KLRALSNELGKAAAKESKESPAEEKEQKQEEPPPPA-------V 231
            ..:||     ||..|...:  |..:.|.|..:.:.::.|:.|...|:::..:||...       .
Mosquito   101 ELETK-----SPSKTKKSKTFKFPSKSKEKREKSREKDKDRPETSKQEESVKPPEKGEKEKDKKK 160

  Fly   232 DPMPLVYEKPHHFKVHTFKGLNWCEFCANFLWGFTAQGVKCEACGFVAHSKCSELVPPKCVPDLK 296
            |......||....|....|.|.              ||...|.                 |.:|.
Mosquito   161 DKEKKEKEKKEKSKDKKEKKLK--------------QGSVSEE-----------------VLELG 194

  Fly   297 RIRGVFGTDLTTMVQLEPHH---QIPFVVRRCVEEVEARGMLQEGIYRVSGFADEIEALKLAL-D 357
            ..:.:||..|....:....|   .:|.|||.|::.::..|:..|.||:|.....:::.||... :
Mosquito   195 DAQPIFGVSLGLATERSRCHDGINLPLVVRDCIDYLQEHGLQSEQIYKVEAVKTKLQQLKRTYNN 259

  Fly   358 REGEKTDMSETAYGNVNVIAGTLKLYLRLLPVPLITFQAYPSFMAAGRTGKQAEQRQLMAEAVRR 422
            |||     |.:...:|.:..|.||::||.||.|::|......|.......:.::|.|.:...|.:
Mosquito   260 REG-----SCSGEMDVPIACGLLKMFLRELPEPILTTDLSSRFEEVASHSQVSQQEQELVCLVEQ 319

  Fly   423 LPPAHHSCLQYMLEHLKRVASHYAVNKMNEHNLATVFAPTLIATPQHMTNLTEEIFMLSSLITHC 487
            ||..:.:.|.:|..|:..|..:....|||..|:|.:.:|||        .::..:|:  :::.||
Mosquito   320 LPSCNRTLLSWMFMHVDAVTQNEDFTKMNAQNIAMLLSPTL--------QMSHRLFV--AILCHC 374

  Fly   488 KTIFA 492
            .|:||
Mosquito   375 STLFA 379

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP5A	NP_727007.1	SH2_a2chimerin_b2chimerin	75..166	CDD:198215	16/90 (18%)
		C1_CHN	241..293	CDD:410356	6/51 (12%)
		RhoGAP_chimaerin	302..491	CDD:239837	52/192 (27%)
Rlip	XP_312836.6	None