Protein Alignment RhoGAP5A and RhoGAP5A

DIOPT Version :10

• Sequence 1: NP_727007.1
• Gene: RhoGAP5A / 31473
• FlyBaseID: FBgn0029778
• Length: 494
• Species: Drosophila melanogaster
• Sequence 2: XP_311850.5
• Gene: RhoGAP5A / 1272926
• VectorBaseID: AGAMI1_012266
• Length: 493
• Species: Anopheles gambiae
• Alignment Length: 492
• Identity: 283/492 - (57%)
• Similarity: 351/492 - (71%)
• Gaps: 37/492 - (7%)

  Fly    19 GVGGAPEPSS-------PVQKVWKPELYKLQLEAPAPCPLRCQRTLPLPPAKSTAEAVEANNLAG 76
            |....|:.|:       .|..||||||||:||:||.|.|:.|:|...:.|.:
Mosquito    19 GQHSGPQSSTMSKDALLAVPNVWKPELYKIQLDAPTPKPVLCERDDIMGPTR------------- 70

  Fly    77 RLYGSEYHGLMGHLEAEQLLANARDGSYFVRRSPQSDGYYTLSLRFNKRPKHYKLLYKPGVGHYL 141
              ||.||||.|.|.|.||:|.:..||||.|||||.:|.||||||||.:..||:|:.|.|..||||
Mosquito    71 --YGKEYHGTMDHKECEQMLKDKPDGSYLVRRSPGADNYYTLSLRFGQATKHFKIFYCPEKGHYL 133

  Fly   142 RGQDKRFDTVHDMVADGLINFHMQLHASPIIQQINQQTKNCYQQSPYMTLNGRKLRAL------- 199
            |...|:|:||.:||||||::|:|:|||:||::::..|||.||:|||||||:.||||:|
Mosquito   134 RENFKKFETVEEMVADGLVDFYMRLHAAPILKEMMSQTKKCYEQSPYMTLHRRKLRSLCKPSKLP 198

  Fly   200 ----SNELGKAAAKESKESPAEEKEQKQEEPPPPAVDPMPLVYEKPHHFKVHTFKGLNWCEFCAN 260
                |.|.......:.::..|:..:|:|.|......:..| .|||.|.||.||||||||||||||
Mosquito   199 MVQDSLESADTEIADDRDGGAKGADQEQFEKSDTHDNAYP-EYEKQHAFKTHTFKGLNWCEFCAN 262

  Fly   261 FLWGFTAQGVKCEACGFVAHSKCSELVPPKCVPDLKRIRGVFGTDLTTMVQLEPHH-QIPFVVRR 324
            ||||||:|||||:.|||:||.|||||||.||||||||:||:||.||||:|  ..|. :|||:|::
Mosquito   263 FLWGFTSQGVKCDDCGFMAHFKCSELVPAKCVPDLKRLRGIFGVDLTTLV--TAHKCRIPFIVKK 325

  Fly   325 CVEEVEARGMLQEGIYRVSGFADEIEALKLALDREGEKTDMSETAYGNVNVIAGTLKLYLRLLPV 389
            ||||||..|||||||||:|||||||||||:|||::|||.|:|...|.|:|||||.||||||||||
Mosquito   326 CVEEVENHGMLQEGIYRISGFADEIEALKMALDKDGEKADVSAQMYSNINVIAGVLKLYLRLLPV 390

  Fly   390 PLITFQAYPSFMAAGRTGKQAEQRQLMAEAVRRLPPAHHSCLQYMLEHLKRVASHYAVNKMNEHN 454
            ||||||::|.||.:.|.....||...:..||:.|||||..||:|:||||.|:|||:.:|||||||
Mosquito   391 PLITFQSFPLFMESMREKSIGEQVIALRNAVKALPPAHLHCLKYILEHLNRIASHHTINKMNEHN 455

  Fly   455 LATVFAPTLIATPQHMTNLTEEIFMLSSLITHCKTIF 491
            |||||||||||||||||:|::||.||::||:||..||
Mosquito   456 LATVFAPTLIATPQHMTDLSQEISMLAALISHCHAIF 492

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP5A	NP_727007.1	SH2_a2chimerin_b2chimerin	75..166	CDD:198215	52/90 (58%)
		C1_CHN	241..293	CDD:410356	42/51 (82%)
		RhoGAP_chimaerin	302..491	CDD:239837	126/189 (67%)
RhoGAP5A	XP_311850.5	None