DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP5A and ARHGAP33

DIOPT Version :9

Sequence 1:	NP_727007.1	Gene:	RhoGAP5A / 31473	FlyBaseID:	FBgn0029778	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	XP_006723062.1	Gene:	ARHGAP33 / 115703	HGNCID:	23085	Length:	1298	Species:	Homo sapiens

Alignment Length:	366	Identity:	99/366 - (27%)
Similarity:	155/366 - (42%)	Gaps:	65/366 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   181 NCYQQSPYMTL--NGRKLRALSNEL-----GKAAAKESKESPAEEKEQKQEE--------PPPPA 230
            ||.....:|.|  :||:| .||.|.     ..|||...|...|:..::...|        ..||.
Human   158 NCGPVLTWMELDNHGRRL-LLSEEASLNIPAVAAAHVIKRYTAQAPDELSFEVGDIVSVIDMPPT 221

  Fly   231 VDPMPLVYEKPHHFKVHTFKGLNWCEFCANFLWGFTAQGVKC-----EACGFVAHSKCSEL---V 287
            .|..  .:.....|:|..|.     ..|..........|:|.     ..||..|....|.|   |
Human   222 EDRS--WWRGKRGFQVGFFP-----SECVELFTERPGPGLKAADADGPPCGIPAPQGISSLTSAV 279

  Fly   288 P-------------PKCVPDLKRIR-------GVFGTDLTTMVQLEPHHQIPFVVRRCVEEVEAR 332
            |             .:..|..:|:|       .|||.||...:. .....:|.|:|.|.|.:||.
Human   280 PRPRGKLAGLLRTFMRSRPSRQRLRQRGILRQRVFGCDLGEHLS-NSGQDVPQVLRCCSEFIEAH 343

  Fly   333 GMLQEGIYRVSGFADEIEALKLALDREGEKTDMSETAY-GNVNVIAGTLKLYLRLLPVPLITFQA 396
            |:: :||||:||.:..|:.|:...|.| ...::|..|: .:::.::...|||.|.||.||:|:|.
Human   344 GVV-DGIYRLSGVSSNIQRLRHEFDSE-RIPELSGPAFLQDIHSVSSLCKLYFRELPNPLLTYQL 406

  Fly   397 YPSFMAAGRTGKQAEQRQLMAEAVRRLPPAHHSCLQYMLEHLKRVASHYAVNKMNEHNLATVFAP 461
            |..|..|.....:.|:...:.:.:::|||.|:..|:|:|.||.|:|.|.|...|:..|||.|:||
Human   407 YGKFSEAMSVPGEEERLVRVHDVIQQLPPPHYRTLEYLLRHLARMARHSANTSMHARNLAIVWAP 471

  Fly   462 TLIATPQ----------HMTNLTEEIFMLSSLITHCKTIFA 492
            .|:.:.:          ....:..:..::..|:||...:|:
Human   472 NLLRSMELESVGMGGAAAFREVRVQSVVVEFLLTHVDVLFS 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP5A	NP_727007.1	SH2_a2chimerin_b2chimerin	75..166	CDD:198215
		C1_1	242..294	CDD:278556	13/72 (18%)
		RhoGAP_chimaerin	302..491	CDD:239837	62/199 (31%)
ARHGAP33	XP_006723062.1	PX_domain	56..168	CDD:295365	3/9 (33%)
		SH3_ARHGAP32_33	190..243	CDD:212769	11/59 (19%)
		RhoGAP_CdGAP	312..506	CDD:239849	61/196 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1300981at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920