Protein Alignment RhoGAP5A and CHN1

DIOPT Version :10

• Sequence 1: NP_727007.1
• Gene: RhoGAP5A / 31473
• FlyBaseID: FBgn0029778
• Length: 494
• Species: Drosophila melanogaster
• Sequence 2: NP_001358443.1
• Gene: CHN1 / 1123
• HGNCID: 1943
• Length: 476
• Species: Homo sapiens
• Alignment Length: 438
• Identity: 171/438 - (39%)
• Similarity: 247/438 - (56%)
• Gaps: 76/438 - (17%)

  Fly    57 LPLPPAKSTAEAVEANNLAGRLYGSEYHGLMGHLEAEQLLANARDGSYFVRRSPQSDGYYTLSLR 121
            ||.||                    .:||::....|:|||..| :|||.:|.|.:..|.|||:||
Human    61 LPQPP--------------------RFHGMISREAADQLLIVA-EGSYLIRESQRQPGTYTLALR 104

  Fly   122 FNKRPKHYKLLYKPGVGHYLRGQDKRFDTVHDMVADGLINFHMQLHASPIIQQINQQTKN-CYQQ 185
            |..:.::::|.|.   |.:..| :|||:::||:|.||||..:::..|:   :.|.:.|.| .|:.
Human   105 FGSQTRNFRLYYD---GKHFVG-EKRFESIHDLVTDGLITLYIETKAA---EYIAKMTINPIYEH 162

  Fly   186 SPYMTLN-------------------------GRKLRALSNELGKAAAKESKESPAEEKEQKQEE 225
            ..|.|||                         |...:.|::.:.:|..||:::.|.
Human   163 VGYTTLNREPAYKKHMPVLKETHDERDSTGQDGVSEKRLTSLVRRATLKENEQIPK--------- 218

  Fly   226 PPPPAVDPMPLVYEKPHHFKVHTFKGLNWCEFCANFLWGFTAQGVKCEACGFVAHSKCSELVPPK 290
                        |||.|:||||||:|.:|||:||||:||..||||||..||...|.:||::||..
Human   219 ------------YEKIHNFKVHTFRGPHWCEYCANFMWGLIAQGVKCADCGLNVHKQCSKMVPND 271

  Fly   291 CVPDLKRIRGVFGTDLTTMVQLEPHHQIPFVVRRCVEEVEARGMLQEGIYRVSGFADEIEALKLA 355
            |.||||.::.|:..||||:|:.....: |.||..|:.|:|:||:..||:||||||:|.||.:|:|
Human   272 CKPDLKHVKKVYSCDLTTLVKAHTTKR-PMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMA 335

  Fly   356 LDREGEKTDMSETAYGNVNVIAGTLKLYLRLLPVPLITFQAYPSFMAAGRTGKQAEQRQLMAEAV 420
            .||:|||.|:|...|.::|:|.|.||||.|.||:||||:.|||.|:.:.:.....||.:.:.||:
Human   336 FDRDGEKADISVNMYEDINIITGALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHEAL 400

  Fly   421 RRLPPAHHSCLQYMLEHLKRVASHYAVNKMNEHNLATVFAPTLIATPQ 468
            :.|||||...|:|::.|||||..|...|.||..||..||.|||:.:|:
Human   401 KLLPPAHCETLRYLMAHLKRVTLHEKENLMNAENLGIVFGPTLMRSPE 448

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP5A	NP_727007.1	SH2_a2chimerin_b2chimerin	75..166	CDD:198215	33/90 (37%)
		C1_CHN	241..293	CDD:410356	31/51 (61%)
		RhoGAP_chimaerin	302..491	CDD:239837	80/167 (48%)
CHN1	NP_001358443.1	SH2	67..145	CDD:472789	33/82 (40%)
		C1_alphaCHN	218..274	CDD:410406	34/76 (45%)
		RhoGAP_chimaerin	283..476	CDD:239837	80/167 (48%)