DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP5A and Abr

DIOPT Version :9

Sequence 1:	NP_727007.1	Gene:	RhoGAP5A / 31473	FlyBaseID:	FBgn0029778	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_932135.1	Gene:	Abr / 109934	MGIID:	107771	Length:	871	Species:	Mus musculus

Alignment Length:	496	Identity:	131/496 - (26%)
Similarity:	200/496 - (40%)	Gaps:	136/496 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 WKPELYKLQ---LEAPAPCPLRCQ---------RTLPLPPAKSTAEAVEANNLAGRLYGSEYHGL 86
            |:..:.|||   |:|.....:..|         ||:...|..|..:..|:..|.|.|: ...|..
Mouse   462 WREAIQKLQKKDLQAFVLSSVELQVLTGSCFKLRTVHNIPVTSNKDDDESPGLYGFLH-VIVHSA 525

  Fly    87 MGHLEAEQLLANARDGS--YFVRRSPQSDGYYTLSLRFNKRPKHYKLLYKPGVGHYLRGQDKRFD 149
            .|..::..|.......|  |||.::.      |...|....||                .|:.|:
Mouse   526 KGFKQSANLYCTLEVDSFGYFVSKAK------TRVFRDTTEPK----------------WDEEFE 568

  Fly   150 TVHDMVADGLINFHMQLHASPIIQQINQQTKNCYQQSPYMTLNGRKLRALSNE-----LGKAAAK 209
                          ::|..|..::.:      ||::....|    |:...:||     :||...:
Mouse   569 --------------IELEGSQSLRIL------CYEKCYDKT----KVNKDNNEIVDKIMGKGQIQ 609

  Fly   210 ESKESPAEEKEQKQEEPPPPAVDPMPLVYEKPHHFKVHTFKGLNWCEFCANFLWGFTAQGVKCEA 274
                                 :||. .|..|..|..|....|:.     ..|...||::.:..
Mouse   610 ---------------------LDPQ-TVESKNWHTDVIEMNGIK-----VEFSMKFTSRDMSL-- 645

  Fly   275 CGFVAHSKCSELVPPKCVPDLKRIRGVFGTDLTTMVQLEPHHQIPFVVRRCVEEVEARGMLQEGI 339
                           |..|. |:..||||..::.:.:.| ..::|::||:|:||||.||:.:.||
Mouse   646 ---------------KRTPS-KKQTGVFGVKISVVTKRE-RSKVPYIVRQCIEEVEKRGIEEVGI 693

  Fly   340 YRVSGFADEIEALKLALDREGEK-----TDMSETAYGNVNVIAGTLKLYLRLLPVPLITFQAYPS 399
            ||:||.|.:|:|||...|...:.     :||      ::|.||||||||.|.||.||:|.:.||:
Mouse   694 YRISGVATDIQALKAVFDANNKDILLMLSDM------DINAIAGTLKLYFRELPEPLLTDRLYPA 752

  Fly   400 FMAAGRTGKQAEQRQLMAEAVRRLPPAHHSCLQYMLEHLKRVASHYAVNKMNEHNLATVFAPTL- 463
            ||........|.:...|...:|.||..:.....::||||||||....:|||:.|||||||.|||
Mouse   753 FMEGIALSDPAAKENCMMHLLRSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATVFGPTLL 817

  Fly   464 ----IATPQHMTNLTE--------EIFMLSSLITHCKTIFA 492
                :.:..|:|:..:        ::.:|...:.|....||
Mouse   818 RPSEVESKAHLTSAADIWSHDVMAQVQVLLYYLQHPPISFA 858

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP5A	NP_727007.1	SH2_a2chimerin_b2chimerin	75..166	CDD:198215	15/92 (16%)
		C1_1	242..294	CDD:278556	7/51 (14%)
		RhoGAP_chimaerin	302..491	CDD:239837	76/206 (37%)
Abr	NP_932135.1	RhoGEF	104..294	CDD:238091
		PH_ABR	289..472	CDD:270172	4/9 (44%)
		C2_ABR	518..638	CDD:176068	32/193 (17%)
		RhoGAP_Bcr	657..852	CDD:239852	75/201 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1094
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940