DRSC/TRiP Functional Genomics Resources

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Protein Alignment RhoGAP5A and RALBP1

DIOPT Version :10

Sequence 1:NP_727007.1 Gene:RhoGAP5A / 31473 FlyBaseID:FBgn0029778 Length:494 Species:Drosophila melanogaster
Sequence 2:NP_006779.1 Gene:RALBP1 / 10928 HGNCID:9841 Length:655 Species:Homo sapiens


Alignment Length:292 Identity:80/292 - (27%)
Similarity:124/292 - (42%) Gaps:56/292 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly   205 KAAAKESKESPAEEKEQKQEEPPPPAVDPMPLVYEKPHHFKVHTFKGLNWCEFCANFLWGFTAQG 269
            |...||.|....:.||:|.:|.....:....:|.:              |.|             
Human   128 KEKPKEEKHKEEKHKEEKHKEKKSKDLTAADVVKQ--------------WKE------------- 165

  Fly   270 VKCEACGFVAHSKCSEL----VPPKCVPDLKRIRGVFGTDLTTMVQLEPHHQIPFVVRRCVEEVE 330
                     ...|...:    ||...||:||.|.|:...|......:....::|.|.|.|::.||
Human   166 ---------KKKKKKPIQEPEVPQIDVPNLKPIFGIPLADAVERTMMYDGIRLPAVFRECIDYVE 221

  Fly   331 ARGMLQEGIYRVSGFADEIEALKLALDREGEKTDMSETAYGNVNVIAGTLKLYLRLLPVPLITFQ 395
            ..||..||||||||...:::.||.|.||| |.|::.:.   ..|.:|..||.|||.||..|:|.:
Human   222 KYGMKCEGIYRVSGIKSKVDELKAAYDRE-ESTNLEDY---EPNTVASLLKQYLRDLPENLLTKE 282

  Fly   396 AYPSF-MAAGRTGKQAEQRQLMAEAVRRLPPAHHSCLQYMLEHLKRVASHYAVNKMNEHNLATVF 459
            ..|.| .|.||| .:.|:.|.....::.||..::..:.:::.|:..|.:.....|||..|::.|.
Human   283 LMPRFEEACGRT-TETEKVQEFQRLLKELPECNYLLISWLIVHMDHVIAKELETKMNIQNISIVL 346

  Fly   460 APTLIATPQHMTNLTEEIFMLSSLITHCKTIF 491
            :||:     .::|....:|     .||.:.:|
Human   347 SPTV-----QISNRVLYVF-----FTHVQELF 368

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGAP5ANP_727007.1 SH2_a2chimerin_b2chimerin 75..166 CDD:198215
C1_CHN 241..293 CDD:410356 5/55 (9%)
RhoGAP_chimaerin 302..491 CDD:239837 59/189 (31%)
RALBP1NP_006779.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..158 8/29 (28%)
Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:Q9PT60 102..119
Mediates association with membranes and could form transmembrane domains. /evidence=ECO:0000269|PubMed:15610018 154..219 17/100 (17%)
RhoGap_RalBP1 190..371 CDD:239846 61/194 (31%)
Mediates interaction with RALA and RALB. /evidence=ECO:0000269|PubMed:20696399, ECO:0000269|PubMed:7673236 403..499
Smc <413..>610 CDD:440809
Mediates interaction with REPS1 and REPS2. /evidence=ECO:0000250|UniProtKB:Q62796 500..655
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 525..551
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 601..655
Blue background indicates that the domain is not in the aligned region.

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