Protein Alignment RhoGAP5A and Chn1

DIOPT Version :9

• Sequence 1: NP_727007.1
• Gene: RhoGAP5A / 31473
• FlyBaseID: FBgn0029778
• Length: 494
• Species: Drosophila melanogaster
• Sequence 2: XP_006498620.2
• Gene: Chn1 / 108699
• MGIID: 1915674
• Length: 541
• Species: Mus musculus
• Alignment Length: 474
• Identity: 191/474 - (40%)
• Similarity: 270/474 - (56%)
• Gaps: 56/474 - (11%)

  Fly     2 PRNTEAGAGNANTGGSGG------VGGAPEPSSPVQKVWKPELYKLQLEAPAPCPLRCQRTLPLP 60
            ||.....|..|.:.|..|      :....|...|   |||..||:||.|||.|..:.|
Mouse    89 PRCRLPAAAGARSAGRRGSTMALTLFDTDEYRPP---VWKSYLYQLQQEAPHPRRVTC------- 143

  Fly    61 PAKSTAEAVEANNLAGRLYGSEYHGLMGHLEAEQLLANARDGSYFVRRSPQSDGYYTLSLRFNKR 125
                   ..|..| ..:.||.||||::...|.:|||:.| :|||.:|.|.:..|.|||:|||..:
Mouse   144 -------TCEVEN-RPKYYGREYHGMISREETDQLLSVA-EGSYLIRESQRQPGTYTLALRFGSQ 199

  Fly   126 PKHYKLLYKPGVGHYLRGQDKRFDTVHDMVADGLINFHMQLHASPIIQQINQQTKN-CYQQSPYM 189
            .::::|.|.   |.:..| :|||:::||:|.||||..:::..|:   :.|.:.|.| .|:...|.
Mouse   200 TRNFRLYYD---GKHFVG-EKRFESIHDLVTDGLITLYIETKAA---EYIAKMTINPIYEHIGYT 257

  Fly   190 TLNGRKLRALSNELGKAAAKESKESPAEEKEQKQEEPPPPAVDPMPLVYEKPHHFKVHTFKGLNW 254
            |||    |..:.:...|..||:.    :|||...::.          |.||    :||||:|.:|
Mouse   258 TLN----REPAYKQHMAVLKETH----DEKEATGQDG----------VSEK----RVHTFRGPHW 300

  Fly   255 CEFCANFLWGFTAQGVKCEACGFVAHSKCSELVPPKCVPDLKRIRGVFGTDLTTMVQLEPHHQIP 319
            ||:||||:||..||||||..||...|.:||::||..|.||||.::.|:..||||:|:.....: |
Mouse   301 CEYCANFMWGLIAQGVKCADCGLNVHKQCSKMVPNDCKPDLKHVKKVYSCDLTTLVKAHITKR-P 364

  Fly   320 FVVRRCVEEVEARGMLQEGIYRVSGFADEIEALKLALDREGEKTDMSETAYGNVNVIAGTLKLYL 384
            .||..|:.|:|:||:..||:||||||:|.||.:|:|.||:|||.|:|...|.::|:|.|.||||.
Mouse   365 MVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRDGEKADISVNMYEDINIITGALKLYF 429

  Fly   385 RLLPVPLITFQAYPSFMAAGRTGKQAEQRQLMAEAVRRLPPAHHSCLQYMLEHLKRVASHYAVNK 449
            |.||:||||:.|||.|:.:.:.....||.:.:.||:|.|||||...|:|::.|||||..|...|.
Mouse   430 RDLPIPLITYDAYPKFIESAKIMDPDEQLETLHEALRSLPPAHCETLRYLMAHLKRVTLHEKENL 494

  Fly   450 MNEHNLATVFAPTLIATPQ 468
            |:..||..||.|||:.:|:
Mouse   495 MSAENLGIVFGPTLMRSPE 513

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP5A	NP_727007.1	SH2_a2chimerin_b2chimerin	75..166	CDD:198215	37/90 (41%)
		C1_1	242..294	CDD:278556	28/51 (55%)
		RhoGAP_chimaerin	302..491	CDD:239837	80/167 (48%)
Chn1	XP_006498620.2	SH2_a2chimerin_b2chimerin	150..236	CDD:198215	37/90 (41%)
		C1_1	291..337	CDD:365894	27/45 (60%)
		RhoGAP_chimaerin	348..541	CDD:239837	80/167 (48%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833675
Domainoid	1	1.000	160	1.000	Domainoid score	I4047
eggNOG	1	0.900	-	-		E1_KOG1453
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H31056
Inparanoid	1	1.050	335	1.000	Inparanoid score	I2393
Isobase	1	0.950	-	0	Normalized mean entropy	S3050
OMA	1	1.010	-	-		QHG49440
OrthoDB	1	1.010	-	-		D1300981at2759
OrthoFinder	1	1.000	-	-		FOG0001164
OrthoInspector	1	1.000	-	-		otm43790
orthoMCL	1	0.900	-	-		OOG6_104322
Panther	1	1.100	-	-	O	PTHR46075
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1094
SonicParanoid	1	1.000	-	-		X2268
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	17.750