DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP5A and arhgap35

DIOPT Version :9

Sequence 1:	NP_727007.1	Gene:	RhoGAP5A / 31473	FlyBaseID:	FBgn0029778	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	XP_004917008.1	Gene:	arhgap35 / 100498460	XenbaseID:	XB-GENE-999477	Length:	1472	Species:	Xenopus tropicalis

Alignment Length:	514	Identity:	125/514 - (24%)
Similarity:	193/514 - (37%)	Gaps:	116/514 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 PEPSSPVQKVWKPELYKLQLEAPAPCPLRCQRTLPLPPAKSTAEAVEANNLAGRLYGSEYHGL-- 86
            ||||        |:....|.|.....|::..|.|         |....|.|..:|.......|
Frog   982 PEPS--------PQHILFQNEPNIAAPIKFTREL---------EETVMNTLESKLNNKVPPPLKP 1029

  Fly    87 -------MGHLEAEQLLANARDGSYFVRRSPQSDGYYTLSLRFNKRPKHY----KLLYKPGVGHY 140
                   :...|...|...||||.   |:|..|..:..|. .|:  |..|    ..:.||
Frog  1030 KPPIPYEITKPELSYLDTGARDGH---RKSLTSINWPPLE-AFD--PSDYAEPMDSVVKP----- 1083

  Fly   141 LRGQDKRFDTV-HDMVADGLINFHMQLHASPIIQQINQQTKNCYQQSPYMTLNGRKL-------- 196
             |.|::...:| ||.....:|.          |:..|:...|.........::...|
Frog  1084 -RNQEENIYSVPHDSTQGKIIT----------IRNTNKPQSNGSGNGSDSDMDTNSLERARKASI 1137

  Fly   197 -------RALSNELGKAAAKESKESPAEEKEQKQEEPPPPAVDPMPLVYEKPHHFKVHTFKGLNW 254
                   |....:|||.::..|..|...:     :||.|        :..|.........||
Frog  1138 VTKPVLYRTKCAKLGKFSSYRSSLSVGSD-----DEPGP--------IRRKEEETGTQGTKG--- 1186

  Fly   255 CEFCANFLWGFTAQGVKCEACGFV-AHSKCSELVPPKCVPDLKRI---RGVFGTDLTTMVQLEPH 315
             :...|   .:.|.|........: :..:.::.|.||..|.|.:.   ...||..|:::|..|
Frog  1187 -DSTTN---SYEADGEDPRKRNILRSLRRTTKKVKPKPRPSLTKATWESNYFGFPLSSVVTSE-- 1245

  Fly   316 HQIPFVVRRCVEEVEA--RGMLQEGIYRVSGFADEIEALKLALDREGEKTDMSETAYGNVNVIAG 378
            ..||..:.:|||.:||  .||..||||||||...|:|:|:...|:: ...|::|..: .||.:||
Frog  1246 RPIPVFIEKCVEYIEATGEGMTTEGIYRVSGNKSEMESLQRQFDQD-HNLDLAEKDF-TVNTVAG 1308

  Fly   379 TLKLYLRLLPVPLITFQAYPSFMAAGRTGKQAEQRQLMAEAVRRLPPAHHSCLQYMLEHLKRVAS 443
            .||.:...||.||:.:......:.|.:......:.|.|.:.:::.|..:|...:|::.||.||:.
Frog  1309 ALKSFFSELPDPLVPYNMQAELVEAYKINDLEHKLQAMKDLLKKFPKENHEIFKYVISHLNRVSQ 1373

  Fly   444 HYAVNKMNEHNLATVFAPTLI-----------ATPQHMTNLTEEIFMLSSLITHCKTIF 491
            |:.:|.|...||:..|.|||:           ||..:.|.:  |:|     |..|...|
Frog  1374 HHHINLMTSENLSICFWPTLMRPDFTTMDALTATRTYQTII--ELF-----IQQCPFFF 1425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP5A	NP_727007.1	SH2_a2chimerin_b2chimerin	75..166	CDD:198215	23/104 (22%)
		C1_1	242..294	CDD:278556	8/52 (15%)
		RhoGAP_chimaerin	302..491	CDD:239837	64/201 (32%)
arhgap35	XP_004917008.1	Ras_like_GTPase	29..245	CDD:206648
		Ras	<158..247	CDD:395024
		RhoGAP-FF1	261..340	CDD:406821
		FF	429..>470	CDD:128718
		FF	485..538	CDD:128718
		pseudoGTPaseD_p190RhoGAP	589..760	CDD:425412
		PHA03151	1036..1225	CDD:177546	44/230 (19%)
		RhoGAP_p190	1234..1420	CDD:239838	63/196 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910