Protein Alignment RhoGAP5A and chn2

DIOPT Version :10

• Sequence 1: NP_727007.1
• Gene: RhoGAP5A / 31473
• FlyBaseID: FBgn0029778
• Length: 494
• Species: Drosophila melanogaster
• Sequence 2: XP_002933428.2
• Gene: chn2 / 100496459
• XenbaseID: XB-GENE-950874
• Length: 467
• Species: Xenopus tropicalis
• Alignment Length: 466
• Identity: 181/466 - (38%)
• Similarity: 270/466 - (57%)
• Gaps: 32/466 - (6%)

  Fly     7 AGAGNANTGGSGGVGGAPEPSSPVQKVWKPELYKLQLEAPAPCPLRCQRTLPLPPAKSTAEAVEA 71
            |.:.|::..|| .|....|...|.  |||..||:||.|||.|              :....::|.
 Frog     2 AASSNSSLSGS-SVSSDAEEYQPT--VWKSYLYQLQQEAPRP--------------RRITSSLEV 49

  Fly    72 NNLAGRLYGSEYHGLMGHLEAEQLLANARDGSYFVRRSPQSDGYYTLSLRFNKRPKHYKLLYKPG 136
            .| ..:.||.|:||::...:|:.:|. ..:|:|.:|.|.:..|.|||:|||..:..:|:|.|.
 Frog    50 VN-RPKHYGREFHGIISREQADVVLC-GMEGAYLIRESQRQPGCYTLALRFGHQTLNYRLFYD-- 110

  Fly   137 VGHYLRGQDKRFDTVHDMVADGLINFHMQLHASPIIQQINQQTKNCYQQSPYMTLNGRKL-RALS 200
             |.:..| :|||:::||:|.||||..:::..|:..|.::.  |...|:|..|.::...|: |.||
 Frog   111 -GKHFVG-EKRFESIHDLVTDGLITLYIETKAAEYIAKMT--TNPIYEQIGYTSMLKDKITRRLS 171

  Fly   201 NELGKAAAKE-SKESPAEEKEQKQEEPPPPAVDPMPLVYEKPHHFKVHTFKGLNWCEFCANFLWG 264
            ....::..|. :.||.:.:|..........|.:.....|||.|:||||||:|.:|||:||||:||
 Frog   172 RTKNESKRKTVTNESKSVDKITSLVRRAAIAKNDNHFNYEKAHNFKVHTFRGPHWCEYCANFMWG 236

  Fly   265 FTAQGVKCEACGFVAHSKCSELVPPKCVPDLKRIRGVFGTDLTTMVQLEPHHQI--PFVVRRCVE 327
            ..||||:|..||...|.:||:.||..|.||||||:.|:..||||:|:.   |..  |.||..|::
 Frog   237 LIAQGVRCSDCGLNVHKQCSKYVPNDCQPDLKRIKKVYSCDLTTLVKA---HNTPRPMVVDMCIQ 298

  Fly   328 EVEARGMLQEGIYRVSGFADEIEALKLALDREGEKTDMSETAYGNVNVIAGTLKLYLRLLPVPLI 392
            |:|.||:..||:||||||.:.||.:|::.||:|::.|:|.|.|.::|:|.|.||||.|.||:|:|
 Frog   299 EIEGRGLKSEGLYRVSGFTEHIEDVKMSFDRDGDRADISSTLYPDINIITGALKLYFRDLPIPVI 363

  Fly   393 TFQAYPSFMAAGRTGKQAEQRQLMAEAVRRLPPAHHSCLQYMLEHLKRVASHYAVNKMNEHNLAT 457
            |:..|..||.|.:.....|:.:.:.||:..|||||:..|::::.|||:||.:...|.|...||..
 Frog   364 TYDTYYKFMEASKISNADERLEAIHEALMLLPPAHYETLRFLMIHLKKVALNEKDNLMGSENLGI 428

  Fly   458 VFAPTLIATPQ 468
            ||.|||:..|:
 Frog   429 VFGPTLMRPPE 439

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP5A	NP_727007.1	SH2_a2chimerin_b2chimerin	75..166	CDD:198215	33/90 (37%)
		C1_CHN	241..293	CDD:410356	30/51 (59%)
		RhoGAP_chimaerin	302..491	CDD:239837	73/169 (43%)
chn2	XP_002933428.2	SH2_a2chimerin_b2chimerin	52..138	CDD:198215	33/90 (37%)
		C1_betaCHN	209..269	CDD:410407	36/59 (61%)
		RhoGAP_chimaerin	274..467	CDD:239837	73/169 (43%)