DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP5A and chn2

DIOPT Version :9

Sequence 1:	NP_727007.1	Gene:	RhoGAP5A / 31473	FlyBaseID:	FBgn0029778	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	XP_002933428.2	Gene:	chn2 / 100496459	XenbaseID:	XB-GENE-950874	Length:	467	Species:	Xenopus tropicalis

Alignment Length:	466	Identity:	181/466 - (38%)
Similarity:	270/466 - (57%)	Gaps:	32/466 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 AGAGNANTGGSGGVGGAPEPSSPVQKVWKPELYKLQLEAPAPCPLRCQRTLPLPPAKSTAEAVEA 71
            |.:.|::..|| .|....|...|.  |||..||:||.|||.|              :....::|.
Frog     2 AASSNSSLSGS-SVSSDAEEYQPT--VWKSYLYQLQQEAPRP--------------RRITSSLEV 49

  Fly    72 NNLAGRLYGSEYHGLMGHLEAEQLLANARDGSYFVRRSPQSDGYYTLSLRFNKRPKHYKLLYKPG 136
            .| ..:.||.|:||::...:|:.:|. ..:|:|.:|.|.:..|.|||:|||..:..:|:|.|.
Frog    50 VN-RPKHYGREFHGIISREQADVVLC-GMEGAYLIRESQRQPGCYTLALRFGHQTLNYRLFYD-- 110

  Fly   137 VGHYLRGQDKRFDTVHDMVADGLINFHMQLHASPIIQQINQQTKNCYQQSPYMTLNGRKL-RALS 200
             |.:..| :|||:::||:|.||||..:::..|:..|.::.  |...|:|..|.::...|: |.||
Frog   111 -GKHFVG-EKRFESIHDLVTDGLITLYIETKAAEYIAKMT--TNPIYEQIGYTSMLKDKITRRLS 171

  Fly   201 NELGKAAAKE-SKESPAEEKEQKQEEPPPPAVDPMPLVYEKPHHFKVHTFKGLNWCEFCANFLWG 264
            ....::..|. :.||.:.:|..........|.:.....|||.|:||||||:|.:|||:||||:||
Frog   172 RTKNESKRKTVTNESKSVDKITSLVRRAAIAKNDNHFNYEKAHNFKVHTFRGPHWCEYCANFMWG 236

  Fly   265 FTAQGVKCEACGFVAHSKCSELVPPKCVPDLKRIRGVFGTDLTTMVQLEPHHQI--PFVVRRCVE 327
            ..||||:|..||...|.:||:.||..|.||||||:.|:..||||:|:.   |..  |.||..|::
Frog   237 LIAQGVRCSDCGLNVHKQCSKYVPNDCQPDLKRIKKVYSCDLTTLVKA---HNTPRPMVVDMCIQ 298

  Fly   328 EVEARGMLQEGIYRVSGFADEIEALKLALDREGEKTDMSETAYGNVNVIAGTLKLYLRLLPVPLI 392
            |:|.||:..||:||||||.:.||.:|::.||:|::.|:|.|.|.::|:|.|.||||.|.||:|:|
Frog   299 EIEGRGLKSEGLYRVSGFTEHIEDVKMSFDRDGDRADISSTLYPDINIITGALKLYFRDLPIPVI 363

  Fly   393 TFQAYPSFMAAGRTGKQAEQRQLMAEAVRRLPPAHHSCLQYMLEHLKRVASHYAVNKMNEHNLAT 457
            |:..|..||.|.:.....|:.:.:.||:..|||||:..|::::.|||:||.:...|.|...||..
Frog   364 TYDTYYKFMEASKISNADERLEAIHEALMLLPPAHYETLRFLMIHLKKVALNEKDNLMGSENLGI 428

  Fly   458 VFAPTLIATPQ 468
            ||.|||:..|:
Frog   429 VFGPTLMRPPE 439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP5A	NP_727007.1	SH2_a2chimerin_b2chimerin	75..166	CDD:198215	33/90 (37%)
		C1_1	242..294	CDD:278556	30/51 (59%)
		RhoGAP_chimaerin	302..491	CDD:239837	73/169 (43%)
chn2	XP_002933428.2	SH2_a2chimerin_b2chimerin	52..138	CDD:198215	33/90 (37%)
		C1_betaCHN	209..269	CDD:410407	36/59 (61%)
		RhoGAP_chimaerin	274..467	CDD:239837	73/169 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	155	1.000	Domainoid score	I4181
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	324	1.000	Inparanoid score	I2457
OMA	1	1.010	-	-		QHG49440
OrthoDB	1	1.010	-	-		D1300981at2759
OrthoFinder	1	1.000	-	-		FOG0001164
OrthoInspector	1	1.000	-	-		otm48963
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1094
SonicParanoid	1	1.000	-	-		X2268
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.010