Protein Alignment RhoGAP5A and arhgap15

DIOPT Version :10

• Sequence 1: NP_727007.1
• Gene: RhoGAP5A / 31473
• FlyBaseID: FBgn0029778
• Length: 494
• Species: Drosophila melanogaster
• Sequence 2: XP_017952790.2
• Gene: arhgap15 / 100485536
• XenbaseID: XB-GENE-6038823
• Length: 550
• Species: Xenopus tropicalis
• Alignment Length: 506
• Identity: 112/506 - (22%)
• Similarity: 211/506 - (41%)
• Gaps: 110/506 - (21%)

  Fly    31 QKVWKP---------------------ELYKLQLEAPAPCPLR-----------CQRTLPLPPAK 63
            ||.|||                     |.:....:.|....:|           ||       ||
 Frog    69 QKTWKPPRSAPPVPPKNNITALSETCNETFDSDAKDPGAVQMRIRNANLKLERLCQ-------AK 126

  Fly    64 STA--EAVEANNLAGRLYGSEYHGLMGHLEAEQLLANARDGSYFVRRSPQSDGYYTLSLRFNKRP 126
            |..  ||.:..:...|.:..::  ::....:|.:|.| |:...|:.::       .::.:..|..
 Frog   127 SLVLDEATKPISRHRRNHSQQF--VLDTSGSENILVN-RNKEGFLNKT-------KIAEKGKKLR 181

  Fly   127 KH----YKLLYKPGVGHYLRGQDKRFDTVHDMVADGLINFHMQLHASPIIQQINQQT--KNCYQQ 185
            |:    |.:|..|.:..|...:|:....:........|:..     ...::..|:::  ||.:|
 Frog   182 KNWVTSYTVLSGPKLEFYKDAKDQTASDLRSSTKQERIDLR-----GASVEWANEKSSRKNVFQ- 240

  Fly   186 SPYMTLNGRK--------------LRALSNELGKAAAKESKESPAEEKEQKQEEPPPPAVDPMPL 236
              ..||:|.:              .||:.|.: .:..:|.|..|.....:|...        :.|
 Frog   241 --ITTLSGNEFLFQSDADITVQEWFRAIRNTI-DSLGREKKSPPLCGNIEKTSN--------IEL 294

  Fly   237 VYEKPHHFKVHTFKGLNWCEFCANFLWGFTAQ--GVKCEACGFVAHSKCSELVPPKCVPDLKRIR 299
            ::.:..:.|.|..:......|..|:....|::  .||.....|::..           |.||.::
 Frog   295 LHLEGENTKEHKHEQRKSLIFKLNYSASDTSERNRVKTRLKKFISRR-----------PSLKTLQ 348

  Fly   300 -------GVFGTDLTTMVQLEPHHQIPFVVRRCVEEVEARGMLQEGIYRVSGFADEIEALKLALD 357
                   .|||..|.|:.:.| :..:|..|.:|:|.||.|||..:|||||||....|:.|:..::
 Frog   349 EKGIIKDQVFGCHLETLCKRE-NETVPRFVTQCIEAVEKRGMDADGIYRVSGNLSTIQKLRFIVN 412

  Fly   358 REGEKTDMSETAYGNVNVIAGTLKLYLRLLPVPLITFQAYPSFMAAGRTGKQAEQRQLMAEAVRR 422
            :| ||.::.::.:.:::|:.|.||::.|.||.||..::.:..|:.|.:..:...:.:.:.:.|..
 Frog   413 QE-EKLNLDDSQWDDIHVVTGALKMFFRELPEPLFPYRFFEQFVEAIKLQESHLRVKALRDLVWN 476

  Fly   423 LPPAHHSCLQYMLEHLKRVASHYAVNKMNEHNLATVFAPTLIATPQHMTNL 473
            ||||:.:.::.:.|||:::.:..:||.|:..:|..||.|||:.....|.|:
 Frog   477 LPPANRNTMKALFEHLRKIVAKASVNLMSTQSLGIVFGPTLLRPESDMGNM 527

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP5A	NP_727007.1	SH2_a2chimerin_b2chimerin	75..166	CDD:198215	14/94 (15%)
		C1_CHN	241..293	CDD:410356	8/53 (15%)
		RhoGAP_chimaerin	302..491	CDD:239837	56/172 (33%)
arhgap15	XP_017952790.2	PH_ARHGAP9-like	164..272	CDD:270053	19/123 (15%)
		RhoGAP_ARHGAP27_15_12_9	358..544	CDD:239868	56/172 (33%)