Protein Alignment RhoGAP5A and arhgap26

DIOPT Version :9

• Sequence 1: NP_727007.1
• Gene: RhoGAP5A / 31473
• FlyBaseID: FBgn0029778
• Length: 494
• Species: Drosophila melanogaster
• Sequence 2: XP_012814023.2
• Gene: arhgap26 / 100145296
• XenbaseID: XB-GENE-1011980
• Length: 771
• Species: Xenopus tropicalis
• Alignment Length: 567
• Identity: 116/567 - (20%)
• Similarity: 203/567 - (35%)
• Gaps: 191/567 - (33%)

  Fly    52 RCQRTLPLPPAKSTAEAVEANNLAGRLYGSEYHGLMGHLEAEQLLANARDGSYFVR-----RSPQ 111
            ||     :..|::..|...|.:|      .|:..::|:||.|::......|...:.     |..|
 Frog    70 RC-----IGDAETDDEICIARSL------QEFAAVLGNLEDERIRMIDNSGEVLISPLEKFRKEQ 123

  Fly   112 SDGYYTLSLRFNKR--------PKHYKL----------------------LYKPGVGHYLRGQD- 145
            ......:..:::|.        .||..|                      .|:..:.:.|:..:
 Frog   124 VGAAKEVKKKYDKESEKYCAMLEKHMNLSSKKKEVLLHEADVQLDQMRQHFYEVSLEYVLKVHEV 188

  Fly   146 ---KRFDTVHDMVA--DGLINFHMQLHASPIIQQIN----------QQTKNCYQQSPYMTLNGRK 195
               |.|:.|..::|  .||..|:.  |...:.:..:          |.|::             :
 Frog   189 QERKMFEFVEPLLAFLQGLFTFYH--HGYELAKDFSDFKTQLSISIQNTRD-------------R 238

  Fly   196 LRALSNELGKAAAKESKESPAEEKEQKQEEPPPPAVDPMPL-----VYEKPHHFKVHTFKGLNWC 255
            .....:|: ::..|:.||:|.|..          |:.|..:     |.||.|.       |.:|.
 Frog   239 FEGTRSEV-ESLMKKMKENPHEHL----------ALSPYTMEGYLYVQEKRHF-------GTSWV 285

  Fly   256 EFCANFLWGFTAQGVKCEACGFVAHSKCSELVP-----------------PKCVPDL-----KR- 297
            :                ..|.:...:|...:||                 ..|:...     ||
 Frog   286 K----------------HYCTYQRETKQMTMVPFDQKSGGKVGEEEIIHLKSCIRRKTESIEKRF 334

  Fly   298 ---IRGVFGTDLTTMVQL---------------EPHH---------------QIPF-VVRRCVEE 328
               :.||....:.||..|               ||.:               .|.| ::|:|::.
 Frog   335 CFDVEGVDRPTVLTMQALSEEDRKLWMEAMDGREPVYNSNKDSQSEGTAQLDNIGFSIIRKCIQA 399

  Fly   329 VEARGMLQEGIYRVSGFADEIE-ALKLALD-REGEKTDMSETAYGNVNVIAGTLKLYLRLLPVPL 391
            ||.||:.::|:||:.|....:: .|...:| :...:|:....:...:..|..:||.|||:||.||
 Frog   400 VETRGINEQGLYRIVGVNSRVQKLLNFLMDPKISPETETEIPSEWEIKTITSSLKTYLRMLPGPL 464

  Fly   392 ITFQAYPSFMAAGRTGKQAEQRQLMAEAVRRLPPAHHSCLQYMLEHLKRVASHYAVNKMNEHNLA 456
            :|:|...||:.|.:...|..:.:.:...:.|||..:...|..::.||..||:|:..|.|...||.
 Frog   465 MTYQFQRSFIKAAKLENQESRIKEIHCLIHRLPEKNRQMLNLLMTHLANVAAHHKQNLMTVANLG 529

  Fly   457 TVFAPTLIATPQHMT----------NLTEEIFMLSSLITHCKTIFAT 493
            .||.|||: .||..|          |:..||     :|.:.:.:|:|
 Frog   530 IVFGPTLL-RPQEETVAAIMDIKFQNIVVEI-----IIENYEKMFST 570

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP5A	NP_727007.1	SH2_a2chimerin_b2chimerin	75..166	CDD:198215	21/131 (16%)
		C1_1	242..294	CDD:278556	8/68 (12%)
		RhoGAP_chimaerin	302..491	CDD:239837	61/231 (26%)
arhgap26	XP_012814023.2	BAR_GRAF	19..225	CDD:153320	28/167 (17%)
		BAR-PH_GRAF_family	267..371	CDD:269953	20/126 (16%)
		RhoGAP_Graf	364..563	CDD:239839	58/204 (28%)
		SH3_GRAF	716..771	CDD:212997

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1094
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940