DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP5A and myo9aa

DIOPT Version :9

Sequence 1:	NP_727007.1	Gene:	RhoGAP5A / 31473	FlyBaseID:	FBgn0029778	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	XP_021333664.1	Gene:	myo9aa / 100006612	ZFINID:	ZDB-GENE-080424-5	Length:	2590	Species:	Danio rerio

Alignment Length:	366	Identity:	94/366 - (25%)
Similarity:	164/366 - (44%)	Gaps:	68/366 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   144 QDKRFDTVHDMV----------------------ADGLINFHMQLHA--SPIIQQINQQTKNCYQ 184
            :|.:.||:.|:|                      .||....:..|:|  ..|:::..:|.:..:.
Zfish  1917 EDGKKDTMVDVVFKKALKEFRVNIFNSYSTALAMDDGKSIRYKDLYALFEQILEKNMRQEQRDWS 1981

  Fly   185 QSP--------------YMTLNGRKLRALSNELGKAAAKESKESPAEEKEQKQEEPPPPAVDPMP 235
            :||              :||    :.:.|.:.||||...:.|:...::.:..:|
Zfish  1982 ESPVKVWVNTFKVFLDEFMT----EHKPLDSSLGKAPKPDRKKRRKKDTDVVEE----------- 2031

  Fly   236 LVYEKPHHFKVHTFKGLNWCEFCANFLWGFTAQGVKCEACGFVAHSKCSELVPPKCV----PDLK 296
               ...|.||...:....:||:|::.:| ...:...|:.|.:..|.||.:.:..||.    |:|.
Zfish  2032 ---HNGHIFKSTQYSIPTYCEYCSSLIW-MMDKACVCKLCRYACHRKCCQKMTTKCSKKYDPELS 2092

  Fly   297 RIRGVFGTDLTTMVQLEPHHQIPFVVRRCVEEVEARGMLQEGIYRVSGFADEIEALKLALDREGE 361
            ..:  ||.:|:.:...|  ..:|.||.:.|..:|..|:..|||||.||..::|:.||..||.:..
Zfish  2093 SRQ--FGVELSRLTNDE--RTVPLVVEKLVNYIEMHGLYTEGIYRKSGSTNKIKELKQGLDTDVN 2153

  Fly   362 KTDMSETAYGNVNVIAGTLKLYLRLLPVPLITFQAYPSFMAAGRTGKQAEQRQLMAEAVRRLPPA 426
            ..::.:.   |:||||...|.:||.||.||:||:.|..|:.|.....:.|..:.:...:.:|...
Zfish  2154 GVNLDDY---NINVIASVFKQWLRDLPNPLMTFELYEEFLRAMGLQDKKEVIRGVYSVIDQLSRT 2215

  Fly   427 HHSCLQYMLEHLKRVASHYAVNKMNEHNLATVFAPTLIATP 467
            |.:.|:.::.||.|:|.....|:|:.:.||.||||.::..|
Zfish  2216 HLNTLERLIFHLVRIALQEETNRMSANALAIVFAPCILRCP 2256

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP5A	NP_727007.1	SH2_a2chimerin_b2chimerin	75..166	CDD:198215	7/43 (16%)
		C1_1	242..294	CDD:278556	14/55 (25%)
		RhoGAP_chimaerin	302..491	CDD:239837	56/166 (34%)
myo9aa	XP_021333664.1	UBQ	7..111	CDD:320785
		MYSc_Myo9	161..1039	CDD:276836
		IQ	1145..1166	CDD:197470
		Activator_LAG-3	<1464..1574	CDD:331748
		C1_1	2035..2083	CDD:278556	12/48 (25%)
		RhoGAP	2096..2281	CDD:295372	56/166 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1453
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810