DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP5A and arhgap35a

DIOPT Version :9

Sequence 1:	NP_727007.1	Gene:	RhoGAP5A / 31473	FlyBaseID:	FBgn0029778	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	XP_001343636.1	Gene:	arhgap35a / 100004299	ZFINID:	ZDB-GENE-120516-2	Length:	1536	Species:	Danio rerio

Alignment Length:	205	Identity:	57/205 - (27%)
Similarity:	95/205 - (46%)	Gaps:	30/205 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   302 FGTDLTTMVQLEPHHQIPFVVRRCVEEVEARGMLQEGIYRVSGFADEIEALKLALDREGE----K 362
            ||..|..:|  .|...||..:.:|:..:|..|:..||||||||...|:|:::...|::..    :
Zfish  1266 FGVPLANVV--TPERPIPLFIEKCIHYIETTGLSTEGIYRVSGNKAEMESMQRQFDQDPNIDLVE 1328

  Fly   363 TDMSETAYGNVNVIAGTLKLYLRLLPVPLITFQAYPSFMAAGRTGKQAEQRQLMAEAVRRLPPAH 427
            .|||      ||.:||.||.:...||.||:.:......:.|.:...:..:...|.:.:||.|..:
Zfish  1329 KDMS------VNTVAGALKSFFSELPDPLVPYSMQVELVEAFKINDREHRLHTMKDVLRRFPREN 1387

  Fly   428 HSCLQYMLEHLKRVASHYAVNKMNEHNLATVFAPTLI-----------ATPQHMTNLTEEIFMLS 481
            :...:|::.||.:|:.:..:|.|...||:..|.|||:           ||..:.|       ::.
Zfish  1388 YDVFKYVITHLNKVSLNSRLNLMTSENLSICFWPTLMRPDFTTMDALTATRTYQT-------IIE 1445

  Fly   482 SLITHCKTIF 491
            :.|..|...|
Zfish  1446 TFIHQCAFFF 1455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP5A	NP_727007.1	SH2_a2chimerin_b2chimerin	75..166	CDD:198215
		C1_1	242..294	CDD:278556
		RhoGAP_chimaerin	302..491	CDD:239837	56/203 (28%)
arhgap35a	XP_001343636.1	RAB	29..247	CDD:197555
		Ras_like_GTPase	29..245	CDD:206648
		RhoGAP-FF1	261..340	CDD:293121
		FF	431..482	CDD:128718
		RhoGAP_p190	1266..1450	CDD:239838	55/198 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910