DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34435 and MYL6B

DIOPT Version :9

Sequence 1:	NP_572233.2	Gene:	CG34435 / 31471	FlyBaseID:	FBgn0085464	Length:	299	Species:	Drosophila melanogaster
Sequence 2:	NP_001186558.1	Gene:	MYL6B / 140465	HGNCID:	29823	Length:	208	Species:	Homo sapiens

Alignment Length:	176	Identity:	48/176 - (27%)
Similarity:	79/176 - (44%)	Gaps:	35/176 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 EIPKLRNIFDLFVVNECDQAAGGEDVAAPTCLDL--GIGIRMTDVADCLRIMGLNPSDDELQQRL 90
            ::.:.:..|:||     |:...|: :....|.|:  .:|...|: |:.|:::| ||..|||:.|
Human    65 QLEEFKEAFELF-----DRVGDGK-ILYSQCGDVMRALGQNPTN-AEVLKVLG-NPKSDELKSR- 120

  Fly    91 EEHVRRRESLGMGMKKIAQRATFELVLTLYCQLAEQEVKEMAKGCIVENVLRVLRSRDSAGTGML 155
                               |..||..|.:...:|    |...:| ..|:.|...|..|..|.|.:
Human   121 -------------------RVDFETFLPMLQAVA----KNRGQG-TYEDYLEGFRVFDKEGNGKV 161

  Fly   156 PYSQLRHLLTTMGNRLDETEVYGVLHRAADINGNVLYEHLVHQLFA 201
            ..::|||:|||:|.::.|.||..||....|.||.:.||..:..:.:
Human   162 MGAELRHVLTTLGEKMTEEEVETVLAGHEDSNGCINYEAFLKHILS 207

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34435	NP_572233.2	FRQ1	17..205	CDD:227455	48/176 (27%)
CG34435	NP_572233.2	FRQ1	<188..297	CDD:227455	3/14 (21%)
MYL6B	NP_001186558.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..51
		PTZ00184	58..207	CDD:185504	48/174 (28%)
		EFh	68..132	CDD:298682	22/91 (24%)
		EFh	68..96	CDD:197492	7/33 (21%)
		EFh	150..205	CDD:238008	21/54 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0030
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23048
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910