Protein Alignment Vsx1 and PHOX2B

DIOPT Version :9

• Sequence 1: NP_001284898.1
• Gene: Vsx1 / 31470
• FlyBaseID: FBgn0263511
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_003915.2
• Gene: PHOX2B / 8929
• HGNCID: 9143
• Length: 314
• Species: Homo sapiens
• Alignment Length: 450
• Identity: 102/450 - (22%)
• Similarity: 132/450 - (29%)
• Gaps: 205/450 - (45%)

  Fly   322 HAHAQAHAHAHAHVHAHAAHAAHAAHAHAHHAEAF--------LGAAGGA--------------- 363
            :.::.|:....|.:...:..:|:|..:....|..|        .||..|.
Human     8 YLNSSAYESCMAGMDTSSLASAYADFSSCSQASGFQYNPIRTTFGATSGCPSLTPGSCSLGTLRD 72

  Fly   364 ------GGNPNSLLAAHGGDVLVGPGGTGPGGKKKNKRRHGRTIFTSSQLEELEKAFKEAHYPDV 422
                  ...|..|...||            |..:|.|:|..||.|||:||:|||:.|.|.||||:
Human    73 HQSSPYAAVPYKLFTDHG------------GLNEKRKQRRIRTTFTSAQLKELERVFAETHYPDI 125

  Fly   423 SARELLSMKTGLAEDRIQVWYQNRRAKWRKTEKCWGHSTKMAEYGLYGAMVRHSLPLPETIIKSA 487
            ..||.|::|..|.|.|:|||:||||||:||.|:....:...|:.|..|                .
Human   126 YTREELALKIDLTEARVQVWFQNRRAKFRKQERAAAAAAAAAKNGSSG----------------K 174

  Fly   488 KEDESVAPWLLGMHKKSLEAAELLKSDESDRETPTSDDTNTSYSAGSTHNSPISSFSISRLLFDA 552
            |.|.|                   :.|||.....|..|     |.|....:|            .
Human   175 KSDSS-------------------RDDESKEAKSTDPD-----STGGPGPNP------------N 203

  Fly   553 PPPAAGSAGGKGHHHHHHHHKGHHHAHVHAQAQAHAHMLLHHQQQQQQQQQQQQHHHHLHAAENS 617
            |.|:.|:.||
Human   204 PTPSCGANGG------------------------------------------------------- 213

  Fly   618 LQQQQVAGTGSGSGSGSGSGTGAGSTGPPAHHPYNQQQHLHHLQQLQQQQQQQQQQAQQQQQHHH 682
                     |.|..|.:|: .||...|.|...|
Human   214 ---------GGGGPSPAGA-PGAAGPGGPGGEP-------------------------------- 236

  Fly   683 HQHHHSVHHMHHHNAAAGYAEAAVAAAAAAAAVAAAANARNAAAAAAVAAASASASAAVT 742
                           ..|.|.||.||||||||.||||.|...|||.......|.....:|
Human   237 ---------------GKGGAAAAAAAAAAAAAAAAAAAAGGLAAAGGPGQGWAPGPGPIT 281

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vsx1	NP_001284898.1	Homeobox	399..451	CDD:278475	32/51 (63%)
PHOX2B	NP_003915.2	Homeobox	102..155	CDD:395001	32/52 (62%)
		polyalanine repeat	241..260		15/18 (83%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0494
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810