DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vsx1 and alx1

DIOPT Version :9

Sequence 1:	NP_001284898.1	Gene:	Vsx1 / 31470	FlyBaseID:	FBgn0263511	Length:	837	Species:	Drosophila melanogaster
Sequence 2:	NP_001038539.1	Gene:	alx1 / 565176	ZFINID:	ZDB-GENE-050419-191	Length:	320	Species:	Danio rerio

Alignment Length:	241	Identity:	80/241 - (33%)
Similarity:	105/241 - (43%)	Gaps:	77/241 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   380 VGPGGTGPG-------GKK-------KNKRRHGRTIFTSSQLEELEKAFKEAHYPDVSARELLSM 430
            |.|..:||.       |:|       ..|||| ||.|||:|||||||.|::.|||||..||.|:|
Zfish    92 VSPATSGPDKTDLDELGEKCDSNVSSSKKRRH-RTTFTSAQLEELEKVFQKTHYPDVYVREQLAM 155

  Fly   431 KTGLAEDRIQVWYQNRRAKWRKTEKCWGHSTKMAEYGLYGAMVRHSLPLPETIIKSAKEDESVAP 495
            :|.|.|.|:|||:|||||||||.|:          ||.......|.         :|..|.|:.|
Zfish   156 RTELTEARVQVWFQNRRAKWRKRER----------YGQIQQAKSHF---------AATYDISMLP 201

  Fly   496 WLLGMHKKSLEAAELLKSDESDRETPTSDDTNTSYSAGSTHNSPISSFSISRLLFDAPP------ 554
                               .:|..:..|::..|..||||   |.:||..|.|   .:||
Zfish   202 -------------------RTDSYSQISNNLWTGPSAGS---SVVSSCMIPR---GSPPCVTSPY 241

  Fly   555 ---PAAGSAGGKGHHHHHHHHKGHHHAHVH---------AQAQAHA 588
               |.|...|..|..:|..:..|.:|..::         :.|.:||
Zfish   242 PHSPRAAEHGYVGFPNHQQNQFGVNHVSLNNFFADSLLASSANSHA 287

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vsx1	NP_001284898.1	Homeobox	399..451	CDD:278475	35/51 (69%)
alx1	NP_001038539.1	Homeobox	123..176	CDD:278475	36/53 (68%)
		Transactivation domain. /evidence=ECO:0000250\|UniProtKB:Q63087	180..320		31/152 (20%)
		OAR	296..313	CDD:281777
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	300..313
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910