Protein Alignment Vsx1 and OTX1

DIOPT Version :10

• Sequence 1: NP_572232.2
• Gene: Vsx1 / 31470
• FlyBaseID: FBgn0263511
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_055377.1
• Gene: OTX1 / 5013
• HGNCID: 8521
• Length: 354
• Species: Homo sapiens
• Alignment Length: 393
• Identity: 102/393 - (25%)
• Similarity: 140/393 - (35%)
• Gaps: 114/393 - (29%)

  Fly   357 LGAAGGAGGNPNSLLAAHGGDVLVGPGGTGPGGKKKNKRRHGRTIFTSSQLEELEKAFKEAHYPD 421
            ||.||.|..             |:.|....|...:|.:|.  ||.||.|||:.||..|.:..|||
Human    15 LGLAGPAMD-------------LLHPSVGYPATPRKQRRE--RTTFTRSQLDVLEALFAKTRYPD 64

  Fly   422 VSARELLSMKTGLAEDRIQVWYQNRRAKWRKTEKCWGHSTKMAEYGLYGAMVRHSLPLPETIIKS 486
            :..||.:::|..|.|.|:|||::|||||.|:.::. |..||.                     :.
Human    65 IFMREEVALKINLPESRVQVWFKNRRAKCRQQQQS-GSGTKS---------------------RP 107

  Fly   487 AKEDESVAPWLLGMHKKSLEAAELLKSDESDRETPTSDDTNTSYSAGSTHNSPISSFSISRLLFD 551
            ||             |||....|...|:.|.:.||.:    .|.||.|:.::..||.:
Human   108 AK-------------KKSSPVRESSGSESSGQFTPPA----VSSSASSSSSASSSSAN------- 148

  Fly   552 APPPAAGSAGGKGHHHHHHHHKGHHHAHVHAQAQAHAHMLLHHQQ-QQQQQQQQQQHHHHLHAAE 615
               |||.:|.|.|         |:..|...:.:...|..:..... ..............|.|..
Human   149 ---PAAAAAAGLG---------GNPVAAASSLSTPAASSIWSPASISPGSAPASVSVPEPLAAPS 201

  Fly   616 NS--LQQQQVAGTGSGSGS-----GSGSGTGAGSTGPPAHH-------PYNQQQHLHHLQQLQQQ 666
            |:  :|:...||..:.:.|     |.|...|.|...|.:.:       .|....|.||    ...
Human   202 NTSCMQRSVAAGAATAAASYPMSYGQGGSYGQGYPTPSSSYFGGVDCSSYLAPMHSHH----HPH 262

  Fly   667 QQQQQQQAQQQQQHHHHQH----------HHSVHHMHHHNAAAG------------YAEAAVAAA 709
            |......:.....||||.|          ||..||.|||....|            |.|...|||
Human   263 QLSPMAPSSMAGHHHHHPHAHHPLSQSSGHHHHHHHHHHQGYGGSGLAFNSADCLDYKEPGAAAA 327

  Fly   710 AAA 712
            ::|
Human   328 SSA 330

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vsx1	NP_572232.2	Homeodomain	395..452	CDD:459649	28/56 (50%)
OTX1	NP_055377.1	Homeodomain	39..95	CDD:459649	28/57 (49%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	91..146		20/93 (22%)
		TF_Otx	178..274	CDD:427350	17/99 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	257..305		15/51 (29%)