Protein Alignment Vsx1 and VSX1

DIOPT Version :9

• Sequence 1: NP_001284898.1
• Gene: Vsx1 / 31470
• FlyBaseID: FBgn0263511
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_055403.2
• Gene: VSX1 / 30813
• HGNCID: 12723
• Length: 365
• Species: Homo sapiens
• Alignment Length: 402
• Identity: 135/402 - (33%)
• Similarity: 175/402 - (43%)
• Gaps: 103/402 - (25%)

  Fly   207 KNSSSSGNGGS-----GGSGSGSGGGNPTSNGLGHLGSPTASNGGSGGGAGVGGSG----GGSGT 262
            ::|.|.|...|     |||..||.........|..|.:...:..|.|.|:|..|..    .|.|.
Human     4 RDSLSDGRTSSRALVPGGSPRGSRPRGFAITDLLGLEAELPAPAGPGQGSGCEGPAVAPCPGPGL 68

  Fly   263 SGSNSSTS----GNG-----GNGGSSGSRS-----------SPAGPHHSAALAAHQHAAAAAAAA 307
            .||:.:..    |.|     |....:.:|:           .|.||..:|.||..:...|.....
Human    69 DGSSLARGALPLGLGLLCGFGTQPPAAARAPCLLLADVPFLPPRGPEPAAPLAPSRPPPALGRQK 133

  Fly   308 HHHAAAAAAAHHAHHAHAQAHAHAHAHVHAHAAHAAHAAHAHAHHAEAFLGAAGGAGGNPNSLLA 372
            ...:.:.:      ...:|:.                                     :.|.|.|
Human   134 RSDSVSTS------DEDSQSE-------------------------------------DRNDLKA 155

  Fly   373 AHGGDVLVGPGGTGPGGKKKNKRRHGRTIFTSSQLEELEKAFKEAHYPDVSARELLSMKTGLAED 437
            :             |...|:.|||| ||:||:.|||||||||.|||||||.|||:|::||.|.||
Human   156 S-------------PTLGKRKKRRH-RTVFTAHQLEELEKAFSEAHYPDVYAREMLAVKTELPED 206

  Fly   438 RIQVWYQNRRAKWRKTEKCWGHSTKMAEYGLYGAMVRHSLPLPETIIKSAKED--ESVAPWLLGM 500
            |||||:|||||||||.||.||.|:.|||||||||||||.:|||::::.||:..  .|.|||||||
Human   207 RIQVWFQNRRAKWRKREKRWGGSSVMAEYGLYGAMVRHCIPLPDSVLNSAEGGLLGSCAPWLLGM 271

  Fly   501 HKKSLEAAELLKSDE-------SDRETPTSDDTNTSYSAGSTHNSP--------ISSFSISRLLF 550
            ||||:.......|::       ||.....|..:.:....||...||        |...|.:|...
Human   272 HKKSMGMIRKPGSEDKLAGLWGSDHFKEGSSQSESGSQRGSDKVSPENGLEDVAIDLSSSARQET 336

  Fly   551 DAPPPAAGSAGG 562
            ....|.||:.||
Human   337 KKVHPGAGAQGG 348

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vsx1	NP_001284898.1	Homeobox	399..451	CDD:278475	40/51 (78%)
VSX1	NP_055403.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..37		9/32 (28%)
		Octapeptide motif	31..38		1/6 (17%)
		DNA_pol3_delta2	<47..>149	CDD:331068	21/144 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	113..167		14/109 (13%)
		Nuclear localization signal. /evidence=ECO:0000255	161..166		2/4 (50%)
		Homeobox	167..220	CDD:306543	41/53 (77%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	290..365		15/59 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0494
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002963
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2566
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	5	4.800