DRSC/TRiP Functional Genomics Resources

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Protein Alignment Vsx1 and ARX

DIOPT Version :9

Sequence 1:NP_001284898.1 Gene:Vsx1 / 31470 FlyBaseID:FBgn0263511 Length:837 Species:Drosophila melanogaster
Sequence 2:NP_620689.1 Gene:ARX / 170302 HGNCID:18060 Length:562 Species:Homo sapiens


Alignment Length:647 Identity:156/647 - (24%)
Similarity:205/647 - (31%) Gaps:235/647 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 KMRTP-----FAIQEILG---------LGAYQQQATASATPSEAPPSPAAT-PPPTANTPANGSL 54
            |.::|     :.|..|||         |||  .|:..:...|.|.|..|.. .|.:::.|....|
Human    17 KSKSPTLLSSYCIDSILGRRSPCKMRLLGA--AQSLPAPLTSRADPEKAVQGSPKSSSAPFEAEL 79

  Fly    55 SAVQQQQQQQQQQQQQQQQLQQQQQQAIDSLRESRSISPDVSRL---SAAAAAAAAAAAHCQLPV 116
            ....:                         ||  |...|...||   :|||||||||||      
Human    80 HLPPK-------------------------LR--RLYGPGGGRLLQGAAAAAAAAAAAA------ 111

  Fly   117 FNPANFYAAAGYAAAADPGNAAAAHHHHMTTLAAAAYLRGFLPPGFSTPHEFRGHFQQHFGAQFA 181
                   |||..|.|...|.|...                  ||..:.|.|      :..||..|
Human   112 -------AAAATATAGPRGEAPPP------------------PPPTARPGE------RPDGAGAA 145

  Fly   182 EQAAARGQEYASSLANASGDEQSPSKNSSSSGNGGS-----------GGSGSGSGGGNPTSNGLG 235
            ..|||.......:|..:...:.|.|::.|...||..           ||.|           |:.
Human   146 AAAAAAAAAAWDTLKISQAPQVSISRSKSYRENGAPFVPPPPALDELGGPG-----------GVT 199

  Fly   236 HLGSPTASNGGSGGGAGVGGSGGGSGTSGSNSSTSGNGGNGG--------------SSGSRSSPA 286
            |   |....|.:||......:|||:||.........:..:..              ...:|:...
Human   200 H---PEERLGVAGGPGSAPAAGGGTGTEDDEEELLEDEEDEDEEEELLEDDEEELLEDDARALLK 261

  Fly   287 GPHHSAALAAHQHAAAAAAAAHHHAAAAAAAHHAHHAHAQAHAHAHAHVHAHAAHAAHAAHAHAH 351
            .|......|....|||||||.                                            
Human   262 EPRRCPVAATGAVAAAAAAAV-------------------------------------------- 282

  Fly   352 HAEAFLGAAGGAGGNPNSLLAAHGGD---------VLVGPGGTGPGGKKKNKRRHGRTIFTSSQL 407
                   |..|...:|...|..|..|         |.:..|.....|..|.|:|..||.|||.||
Human   283 -------ATEGGELSPKEELLLHPEDAEGKDGEDSVCLSAGSDSEEGLLKRKQRRYRTTFTSYQL 340

  Fly   408 EELEKAFKEAHYPDVSARELLSMKTGLAEDRIQVWYQNRRAKWRKTEKCWGHSTKMAEYGLYGAM 472
            ||||:||::.|||||..||.|:|:..|.|.|:|||:|||||||||.||.             ||.
Human   341 EELERAFQKTHYPDVFTREELAMRLDLTEARVQVWFQNRRAKWRKREKA-------------GAQ 392

  Fly   473 VR-HSLPLPETIIKSAKEDESVAPWL----LGMHKKSLEAA-------------ELLKSDESDRE 519
            .. ..||.|..:    .....::|:|    ...|..:|::|             .|.....|...
Human   393 THPPGLPFPGPL----SATHPLSPYLDASPFPPHHPALDSAWTAAAAAAAAAFPSLPPPPGSASL 453

  Fly   520 TPTSDDTNTSYSAGS-----------------THNSPISSFSISRLLFDAPPPAAGSAGGKG 564
            .|:......|...|:                 :..:|::|.|.:..|...|.||...|...|
Human   454 PPSGAPLGLSTFLGAAVFRHPAFISPAFGRLFSTMAPLTSASTAAALLRQPTPAVEGAVASG 515

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Vsx1NP_001284898.1 Homeobox 399..451 CDD:278475 34/51 (67%)
ARXNP_620689.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..21 1/3 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 50..81 7/30 (23%)
GCG-encoded polyalanine repeat 102..111 8/8 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 118..255 33/174 (19%)
Homeobox 332..385 CDD:395001 35/52 (67%)
OAR 526..544 CDD:397759
OAR. /evidence=ECO:0000255|PROSITE-ProRule:PRU00138 530..543
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
32.870

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