DRSC/TRiP Functional Genomics Resources

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Protein Alignment Vsx1 and ARX

DIOPT Version :10

Sequence 1:NP_572232.2 Gene:Vsx1 / 31470 FlyBaseID:FBgn0263511 Length:837 Species:Drosophila melanogaster
Sequence 2:NP_620689.1 Gene:ARX / 170302 HGNCID:18060 Length:562 Species:Homo sapiens


Alignment Length:647 Identity:156/647 - (24%)
Similarity:205/647 - (31%) Gaps:235/647 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 KMRTP-----FAIQEILG---------LGAYQQQATASATPSEAPPSPAAT-PPPTANTPANGSL 54
            |.::|     :.|..|||         |||  .|:..:...|.|.|..|.. .|.:::.|....|
Human    17 KSKSPTLLSSYCIDSILGRRSPCKMRLLGA--AQSLPAPLTSRADPEKAVQGSPKSSSAPFEAEL 79

  Fly    55 SAVQQQQQQQQQQQQQQQQLQQQQQQAIDSLRESRSISPDVSRL---SAAAAAAAAAAAHCQLPV 116
            ....:                         ||  |...|...||   :|||||||||||      
Human    80 HLPPK-------------------------LR--RLYGPGGGRLLQGAAAAAAAAAAAA------ 111

  Fly   117 FNPANFYAAAGYAAAADPGNAAAAHHHHMTTLAAAAYLRGFLPPGFSTPHEFRGHFQQHFGAQFA 181
                   |||..|.|...|.|...                  ||..:.|.|      :..||..|
Human   112 -------AAAATATAGPRGEAPPP------------------PPPTARPGE------RPDGAGAA 145

  Fly   182 EQAAARGQEYASSLANASGDEQSPSKNSSSSGNGGS-----------GGSGSGSGGGNPTSNGLG 235
            ..|||.......:|..:...:.|.|::.|...||..           ||.|           |:.
Human   146 AAAAAAAAAAWDTLKISQAPQVSISRSKSYRENGAPFVPPPPALDELGGPG-----------GVT 199

  Fly   236 HLGSPTASNGGSGGGAGVGGSGGGSGTSGSNSSTSGNGGNGG--------------SSGSRSSPA 286
            |   |....|.:||......:|||:||.........:..:..              ...:|:...
Human   200 H---PEERLGVAGGPGSAPAAGGGTGTEDDEEELLEDEEDEDEEEELLEDDEEELLEDDARALLK 261

  Fly   287 GPHHSAALAAHQHAAAAAAAAHHHAAAAAAAHHAHHAHAQAHAHAHAHVHAHAAHAAHAAHAHAH 351
            .|......|....|||||||.                                            
Human   262 EPRRCPVAATGAVAAAAAAAV-------------------------------------------- 282

  Fly   352 HAEAFLGAAGGAGGNPNSLLAAHGGD---------VLVGPGGTGPGGKKKNKRRHGRTIFTSSQL 407
                   |..|...:|...|..|..|         |.:..|.....|..|.|:|..||.|||.||
Human   283 -------ATEGGELSPKEELLLHPEDAEGKDGEDSVCLSAGSDSEEGLLKRKQRRYRTTFTSYQL 340

  Fly   408 EELEKAFKEAHYPDVSARELLSMKTGLAEDRIQVWYQNRRAKWRKTEKCWGHSTKMAEYGLYGAM 472
            ||||:||::.|||||..||.|:|:..|.|.|:|||:|||||||||.||.             ||.
Human   341 EELERAFQKTHYPDVFTREELAMRLDLTEARVQVWFQNRRAKWRKREKA-------------GAQ 392

  Fly   473 VR-HSLPLPETIIKSAKEDESVAPWL----LGMHKKSLEAA-------------ELLKSDESDRE 519
            .. ..||.|..:    .....::|:|    ...|..:|::|             .|.....|...
Human   393 THPPGLPFPGPL----SATHPLSPYLDASPFPPHHPALDSAWTAAAAAAAAAFPSLPPPPGSASL 453

  Fly   520 TPTSDDTNTSYSAGS-----------------THNSPISSFSISRLLFDAPPPAAGSAGGKG 564
            .|:......|...|:                 :..:|::|.|.:..|...|.||...|...|
Human   454 PPSGAPLGLSTFLGAAVFRHPAFISPAFGRLFSTMAPLTSASTAAALLRQPTPAVEGAVASG 515

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Vsx1NP_572232.2 Homeodomain 395..452 CDD:459649 36/56 (64%)
ARXNP_620689.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..21 1/3 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 50..81 7/30 (23%)
GCG-encoded polyalanine repeat 102..111 8/8 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 118..255 33/174 (19%)
Homeodomain 329..385 CDD:459649 36/55 (65%)
OAR 526..544 CDD:461067
OAR. /evidence=ECO:0000255|PROSITE-ProRule:PRU00138 530..543
Blue background indicates that the domain is not in the aligned region.

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