DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vsx1 and Alx4

DIOPT Version :9

Sequence 1:	NP_001284898.1	Gene:	Vsx1 / 31470	FlyBaseID:	FBgn0263511	Length:	837	Species:	Drosophila melanogaster
Sequence 2:	NP_031468.1	Gene:	Alx4 / 11695	MGIID:	108359	Length:	399	Species:	Mus musculus

Alignment Length:	307	Identity:	86/307 - (28%)
Similarity:	111/307 - (36%)	Gaps:	84/307 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   180 FAEQAAARGQEYASSLANASGDEQSPSKNSSSSGNGGSGGSGSGSGGGNPTSNGLGHLGSPTASN 244
            :.|..||....|.|.:        |.|:..||...|..||.               ..|:...|.
Mouse     9 YCESPAAAMDAYYSPV--------SQSREGSSPFRGFPGGD---------------KFGTTFLSA 50

  Fly   245 GGSGGGAGVGGSGGGSGTSGSNSST---SGNGGNGGSSGSRSSPAGPHHSAALAAHQHAAAAAAA 306
            |..|.|.|...|....|....:.:.   |.:|..|..:..:..|..|        ....|..|..
Mouse    51 GAKGQGFGDAKSRARYGAGQQDLAAPLESSSGARGSFNKFQPQPPTP--------QPPPAPPAPP 107

  Fly   307 AHHHAAAAAA------------AHHAHHAHAQAHAHAHAHVHAHAAHAAHAAHAHAHHAEAFLGA 359
            ||.:....|.            ....|:|..|...:|                ..::..|..|..
Mouse   108 AHLYLQRGACKTPPDGSLKLQEGSGGHNAALQVPCYA----------------KESNLGEPELPP 156

  Fly   360 AGGAGGNPNSLLAAHGGDVLVGPGGTGPGGK----------------KKNKRRHGRTIFTSSQLE 408
            .....|..||.|:      :...|..||..:                .|.|:|..||.|||.|||
Mouse   157 DSEPVGMDNSYLS------VKETGAKGPQDRASAEIPSPLEKTDSESNKGKKRRNRTTFTSYQLE 215

  Fly   409 ELEKAFKEAHYPDVSARELLSMKTGLAEDRIQVWYQNRRAKWRKTEK 455
            ||||.|::.|||||.|||.|:|:|.|.|.|:|||:|||||||||.|:
Mouse   216 ELEKVFQKTHYPDVYAREQLAMRTDLTEARVQVWFQNRRAKWRKRER 262

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vsx1	NP_001284898.1	Homeobox	399..451	CDD:278475	36/51 (71%)
Alx4	NP_031468.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	68..133		10/72 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	171..206		6/34 (18%)
		Homeobox	206..258	CDD:278475	36/51 (71%)
		OAR	375..392	CDD:281777
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	379..392
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	2	1.870