DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vsx2 and LHX4

DIOPT Version :9

Sequence 1:	NP_001284897.1	Gene:	Vsx2 / 31469	FlyBaseID:	FBgn0263512	Length:	645	Species:	Drosophila melanogaster
Sequence 2:	NP_203129.1	Gene:	LHX4 / 89884	HGNCID:	21734	Length:	390	Species:	Homo sapiens

Alignment Length:	250	Identity:	63/250 - (25%)
Similarity:	87/250 - (34%)	Gaps:	84/250 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   231 RHSRTIFTSYQLEKLEEAFKEAHYPDVYAREMLSLKTELPEDRIQVWFQNRRAKWRKTEKVWGGS 295
            :..||..|:.|||.|:.|:|.:..|..:.||.||.:|.|....:||||||||||.::.:|..|
Human   158 KRPRTTITAKQLETLKNAYKNSPKPARHVREQLSSETGLDMRVVQVWFQNRRAKEKRLKKDAG-- 220

  Fly   296 TIMAEYGLYGAMVRHSLPLPDTILKSAKDNDAVAPWLLGMEQKCMHR---KSIEAQSALKDDSGV 357
                         ||.                   |  |...|.:.|   .|.:.:.:..:|.||
Human   221 -------------RHR-------------------W--GQFYKSVKRSRGSSKQEKESSAEDCGV 251

  Fly   358 SD-----HEDSAGSKSAHS-----------------------------EDLSRSRCHALSSSTES 388
            ||     .||...|:..|:                             :||.....:.:..|..|
Human   252 SDSELSFREDQILSELGHTNRIYGNVGDVTGGQLMNGSFSMDGTGQSYQDLRDGSPYGIPQSPSS 316

  Fly   389 LNVVSPAPSSCPTSASTSAPPTSTSG---YAGAASS-----AATTPTGASTTNSS 435
               :|..||..|..........|..|   :||...|     .|..||...:|.||
Human   317 ---ISSLPSHAPLLNGLDYTVDSNLGIIAHAGQGVSQTLRAMAGGPTSDISTGSS 368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vsx2	NP_001284897.1	Homeobox	233..286	CDD:278475	26/52 (50%)
Vsx2	NP_001284897.1	OAR	556..570	CDD:281777
LHX4	NP_203129.1	LIM1_Lhx4	30..81	CDD:188852
		LIM2_Lhx3_Lhx4	89..144	CDD:188762
		Homeobox	160..213	CDD:306543	26/52 (50%)
		Interaction with DNA. /evidence=ECO:0000305\|PubMed:28473536	161..181		9/19 (47%)
		Interaction with 5-mCpG DNA. /evidence=ECO:0000305\|PubMed:28473536	199..211		8/11 (73%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	230..253		5/22 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	356..390		5/12 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1174754at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.010