Protein Alignment Vsx2 and PHOX2B

DIOPT Version :10

• Sequence 1: NP_001284897.1
• Gene: Vsx2 / 31469
• FlyBaseID: FBgn0263512
• Length: 645
• Species: Drosophila melanogaster
• Sequence 2: NP_003915.2
• Gene: PHOX2B / 8929
• HGNCID: 9143
• Length: 314
• Species: Homo sapiens
• Alignment Length: 351
• Identity: 99/351 - (28%)
• Similarity: 119/351 - (33%)
• Gaps: 145/351 - (41%)

  Fly   183 AQGF---PQLKSFAAGAGTCLPGSLAPKDFGMESLNGFGVGP------------NSKKKKKKRRH 232
            |.||   |...:|.|.:| |  .||.|....:.:|......|            ....:|:|:|.
Human    39 ASGFQYNPIRTTFGATSG-C--PSLTPGSCSLGTLRDHQSSPYAAVPYKLFTDHGGLNEKRKQRR 100

  Fly   233 SRTIFTSYQLEKLEEAFKEAHYPDVYAREMLSLKTELPEDRIQVWFQNRRAKWRKTEKVWGGSTI 297
            .||.|||.||::||..|.|.||||:|.||.|:||.:|.|.|:||||||||||:||.|:....:..
Human   101 IRTTFTSAQLKELERVFAETHYPDIYTREELALKIDLTEARVQVWFQNRRAKFRKQERAAAAAAA 165

  Fly   298 MAEYGLYGAMVRHSLPLPDTILKSAKDNDAVAPWLLGMEQKCMHRKSIEAQSALKDDSGVSDHED 362
            .|:.|                                             .|..|.||...|.
Human   166 AAKNG---------------------------------------------SSGKKSDSSRDDE-- 183

  Fly   363 SAGSKSAHSEDLSRSRCHALSSSTESLNVVSPAPSSCPTSASTSAPPTSTSGYAGAASSAATTPT 427
               ||.|.|.|         ..||.     .|.|:..||      |....:|..|
Human   184 ---SKEAKSTD---------PDSTG-----GPGPNPNPT------PSCGANGGGG---------- 215

  Fly   428 GASTTNSSSSPHIELGSPSPQQQQHLQLQQQQQQQASLYLGAGAV-VTGCAPPSYHPLLDAANAA 491
                           |.|||                     |||. ..|...|...|....|.||
Human   216 ---------------GGPSP---------------------AGAPGAAGPGGPGGEPGKGGAAAA 244

  Fly   492 GAGAAASSKDFHMIMNTAVAAAAAAA 517
            .|.|||:          |.|||||||
Human   245 AAAAAAA----------AAAAAAAAA 260

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vsx2	NP_001284897.1	Homeodomain	230..287	CDD:459649	35/56 (63%)
		OAR	556..572	CDD:461067
PHOX2B	NP_003915.2	Homeodomain	99..155	CDD:459649	35/55 (64%)
		polyalanine repeat	241..260		13/28 (46%)