Protein Alignment Vsx2 and ALX1

DIOPT Version :10

• Sequence 1: NP_001284897.1
• Gene: Vsx2 / 31469
• FlyBaseID: FBgn0263512
• Length: 645
• Species: Drosophila melanogaster
• Sequence 2: NP_008913.2
• Gene: ALX1 / 8092
• HGNCID: 1494
• Length: 326
• Species: Homo sapiens
• Alignment Length: 438
• Identity: 99/438 - (22%)
• Similarity: 135/438 - (30%)
• Gaps: 197/438 - (44%)

  Fly   164 PPPPMQHH---------HPHHPHHPLLHAQGFPQLKSFAAGAGTCLPGSLAPKDFGME---SLNG 216
            |.|..:||         .....::.:...:|.|...........|....::|.. ||:   .|:.
Human    55 PLPRAEHHVRLERTSPCQDSSVNYGITKVEGQPLHTELNRAMDNCNSLRMSPVK-GMQEKGELDE 118

  Fly   217 FGVGPNSKKKKKKRRHSRTIFTSYQLEKLEEAFKEAHYPDVYAREMLSLKTELPEDRIQVWFQNR 281
            .|...:|.....|:|..||.|||.|||:||:.|::.||||||.||.|:|:|||.|.|:|||||||
Human   119 LGDKCDSNVSSSKKRRHRTTFTSLQLEELEKVFQKTHYPDVYVREQLALRTELTEARVQVWFQNR 183

  Fly   282 RAKWRKTEKVWGGSTIMAEYGLYGAMVRHSLPLPDTILKSAKDNDAVAPWLLGMEQKCMHRKSIE 346
            ||||||.|:             ||.:
Human   184 RAKWRKRER-------------YGQI--------------------------------------- 196

  Fly   347 AQSALKDDSGVSDHEDSAGSKSAHSEDLSRSRCHALSSSTESLNVVSPAPSSCPTSASTSAPPTS 411
                           ..|.|..|.:.|:|                |.|...|.|
Human   197 ---------------QQAKSHFAATYDIS----------------VLPRTDSYP----------- 219

  Fly   412 TSGYAGAASSAATTPTGASTTNSSSSPHIELGSPSPQQQQHLQLQQQQQQQASLYLG---AGAVV 473
                                                            |.|.:|:.|   .|:||
Human   220 ------------------------------------------------QIQNNLWAGNASGGSVV 236

  Fly   474 TGC----------APPSYHPLLDAANAAGAGAAASSKDF-HMIMNTAVA-AAAAAAQQQHQQQQQ 526
            |.|          .|.|:.|..|::.   .|.:.....| |:.:|.... :....|...|
Human   237 TSCMLPRDTSSCMTPYSHSPRTDSSY---TGFSNHQNQFSHVPLNNFFTDSLLTGATNGH----- 293

  Fly   527 QQQQATATAPGLHAHNLAAALMEHDPDAFRNNSIACLRAKAQEHQARL 574
                |..|.|....               |::|||.||.||:||.|.:
Human   294 ----AFETKPEFER---------------RSSSIAVLRMKAKEHTANI 322

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vsx2	NP_001284897.1	Homeodomain	230..287	CDD:459649	38/56 (68%)
		OAR	556..572	CDD:461067	10/15 (67%)
ALX1	NP_008913.2	Homeodomain	133..189	CDD:459649	38/55 (69%)
		Transactivation domain. /evidence=ECO:0000250|UniProtKB:Q63087	192..326		44/300 (15%)
		OAR	302..320	CDD:461067	10/32 (31%)
		OAR. /evidence=ECO:0000255|PROSITE-ProRule:PRU00138	306..319		8/12 (67%)