Protein Alignment Vsx2 and ALX1

DIOPT Version :9

• Sequence 1: NP_001284897.1
• Gene: Vsx2 / 31469
• FlyBaseID: FBgn0263512
• Length: 645
• Species: Drosophila melanogaster
• Sequence 2: NP_008913.2
• Gene: ALX1 / 8092
• HGNCID: 1494
• Length: 326
• Species: Homo sapiens
• Alignment Length: 435
• Identity: 99/435 - (22%)
• Similarity: 136/435 - (31%)
• Gaps: 191/435 - (43%)

  Fly   164 PPPPMQHH---------HPHHPHHPLLHAQGFPQLKSFAAGAGTCLPGSLAPKDFGME---SLNG 216
            |.|..:||         .....::.:...:|.|...........|....::|.. ||:   .|:.
Human    55 PLPRAEHHVRLERTSPCQDSSVNYGITKVEGQPLHTELNRAMDNCNSLRMSPVK-GMQEKGELDE 118

  Fly   217 FGVGPNSKKKKKKRRHSRTIFTSYQLEKLEEAFKEAHYPDVYAREMLSLKTELPEDRIQVWFQNR 281
            .|...:|.....|:|..||.|||.|||:||:.|::.||||||.||.|:|:|||.|.|:|||||||
Human   119 LGDKCDSNVSSSKKRRHRTTFTSLQLEELEKVFQKTHYPDVYVREQLALRTELTEARVQVWFQNR 183

  Fly   282 RAKWRKTEKVWGGSTIMAEYGLYGAMVRHSLPLPDTILKSAKDNDAVAPWLLGMEQKCMHRKSIE 346
            ||||||.|:             ||.:
Human   184 RAKWRKRER-------------YGQI--------------------------------------- 196

  Fly   347 AQSALKDDSGVSDHEDSAGSKSAHSEDLSRSRCHALSSSTESLNVVSPAPSSCPTSASTSAPPTS 411
                           ..|.|..|.:.|:|                |.|        .:.|.|...
Human   197 ---------------QQAKSHFAATYDIS----------------VLP--------RTDSYPQIQ 222

  Fly   412 TSGYAGAASSAATTPTGASTTNSSSSPHIELGSPSPQQQQHLQLQQQQQQQASLYLGAGAVVTGC 476
            .:.:||.||                                                .|:|||.|
Human   223 NNLWAGNAS------------------------------------------------GGSVVTSC 239

  Fly   477 ----------APPSYHPLLDAANAAGAGAAASSKDF-HMIMNTAVA-AAAAAAQQQHQQQQQQQQ 529
                      .|.|:.|..|::.   .|.:.....| |:.:|.... :....|...|
Human   240 MLPRDTSSCMTPYSHSPRTDSSY---TGFSNHQNQFSHVPLNNFFTDSLLTGATNGH-------- 293

  Fly   530 QATATAPGLHAHNLAAALMEHDPDAFRNNSIACLRAKAQEHQARL 574
             |..|.|....               |::|||.||.||:||.|.:
Human   294 -AFETKPEFER---------------RSSSIAVLRMKAKEHTANI 322

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vsx2	NP_001284897.1	Homeobox	233..286	CDD:278475	36/52 (69%)
		OAR	556..570	CDD:281777	8/13 (62%)
ALX1	NP_008913.2	Homeobox	135..189	CDD:365835	37/53 (70%)
		Transactivation domain. /evidence=ECO:0000250|UniProtKB:Q63087	192..326		44/297 (15%)
		OAR	302..320	CDD:367680	10/32 (31%)
		OAR. /evidence=ECO:0000255|PROSITE-ProRule:PRU00138	306..319		8/12 (67%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D454642at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	3	2.880